Evidence map›Paper›PMID 28639626›Full record

ArticleClinical kidney journal2017

Circulating miRNAs as biomarkers of kidney disease.

Alexander Hüttenhofer, Gert Mayer

Open access · goldAbstract readEditorial
In one paragraph

Article in Clinical kidney journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  3. Review
  4. Article
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  8. Article
  9. Review
  10. Urinary Extracellular Vesicles Magic Particles for Biomarker Discovery.Advances in experimental medicine and biology · 2021
    Article
  11. Review
  12. Epigenetics in kidney diseases.Advances in clinical chemistry · 2021
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Urinary microRNA in kidney disease: utility and roles.American journal of physiology. Renal physiology · 2019
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexander HüttenhoferDivision of Genomics and RNomics, Biocenter Innsbruck, Medical University Innsbruck, Innsbruck, Austria.
Gert MayerDepartment of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
Innsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interest in microRNAs (miRNAs) has dramatically increased in recent years not only because they regulate mRNA expression, and thus many physiological or pathophysiological processes, but also because they could serve as biomarkers. Next to analysis of tissue miRNA expression, measurement in body fluids such as blood or urine is attractive because miRNA in microvesicles or bound to protein is very stable. Currently it is unclear whether these circulating miRNAs are tissue and disease specific or represent more general pathologies like inflammation. In addition pre-analytical sample handling and variable analysis techniques affect the results and thus much more work needs to be done before one can draw a final conclusion about their clinical utility.

Indexed as

analysis techniquebiomarkercirculating microRNAkidney functionrenal disease

Identifiers

PMID28639626
PMCPMC5469550
OpenAlexW2516163214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.