ArticlePharmacogenomics2017
Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.
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Article in Pharmacogenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Pooled it
- Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.The pharmacogenomics journal · 2020Pooled it
- Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Asthma Hospitalizations in Children Before and After COVID-19: Insights from Northern Colombia.Clinics and practice · 2025Article
- Precision Medicine in Asthma Therapy.Handbook of experimental pharmacology · 2023Article
- An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort.The World Allergy Organization journal · 2022Article
- Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response.Clinical and translational allergy · 2022Article
- Pharmacogenomics of Leukotriene Modifiers: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2022Article
- Review
- Identification ofJournal of personalized medicine · 2021Article
- Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use.The European respiratory journal · 2021Article
- LTA4H rs2660845 association with montelukast response in early and late-onset asthma.PloS one · 2021Article
- IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids.Allergy · 2020Article
- Pharmacogenetics of Pediatric Asthma: Current Perspectives.Pharmacogenomics and personalized medicine · 2020Review
- Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases.The Journal of clinical investigation · 2019Review
- Genomic Predictors of Asthma Phenotypes and Treatment Response.Frontiers in pediatrics · 2019Review
- Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review.Clinical and translational allergy · 2019Review
- 17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use.Allergy · 2018Article
- Pharmacogenetics of Antidiabetic Drugs.Advances in pharmacology (San Diego, Calif.) · 2018Review
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Authors and funding
46 authors.
Niloufar FarzanDivision of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Susanne J VijverbergDivision of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Anand K AndiappanSingapore Immunology Network, Agency for Science, Technology & Research, Singapore 138648, Singapore.
Lambang AriantoCopenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Vojko BerceDepartment of Pediatrics, University Medical Centre Maribor, Maribor, Slovenia.
Natalia Blanca-LópezAllergy Service, Infanta Leonor Hospital, Madrid, Spain.
Hans BisgaardCopenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Klaus BønnelykkeCopenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Esteban G BurchardDepartments of Medicine, Bioengineering & Therapeutic Sciences University of California, San Francisco, CA 94110, USA.
Paloma CampoAllergy Unit, IBIMA, Regional University Hospital of Malaga, Malaga, Spain.
Glorisa CaninoBehavioral Sciences institute, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
Bruce CarletonDepartment of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Juan C CeledónDivision of Pulmonary Medicine, Allergy, & Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Fook Tim ChewDepartment of Biological Sciences, National University of Singapore, Singapore, & the Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore.
Wen Chin ChiangDepartment of Biological Sciences, National University of Singapore, Singapore, & the Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore.
Michelle M CloutierAsthma Center, Connecticut Children's Medical Center, University of Connecticut Health Center, CT 06106, USA.
Denis DaleyRespiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada.
Herman T Den DekkerDepartment of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
F Nicole DijkDepartment of Pediatric Pulmonology & Pediatric Allergology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.
Liesbeth DuijtsDepartment of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Carlos FloresCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Erick FornoDivision of Pulmonary Medicine, Allergy, & Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Daniel B HawcuttAlder Hey Children's Hospital, Liverpool, UK.
Natalia Hernandez-PachecoResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Johan C de JongsteDepartment of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Michael KabeschDepartment of Pediatric Pneumology & Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
Gerard H KoppelmanDepartment of Pediatric Pulmonology & Pediatric Allergology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.
Vangelis G ManolopoulosLaboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Somnath MukhopadhyayAcademic Department of Paediatrics, Brighton & Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.
Sara NilssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Colin N PalmerPopulation Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital & Medical School University of Dundee, Dundee, UK.
Maria Pino-YanesCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Munir PirmohamedDepartment of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Uros PotočnikCentre for Human Molecular Genetics & Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Jan A RaaijmakersDivision of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Katja RepnikCentre for Human Molecular Genetics & Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Maximilian SchieckDepartment of Pediatric Pneumology & Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
Yang Yie SioDepartment of Biological Sciences, National University of Singapore, Singapore, & the Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore.
Rosalind L SmythGreat Ormond Street Institute of Child Health, University College London, London, UK.
Csaba SzalaiDepartment of Genetics, Cell & Immuno-biology, Semmelweis University, Budapest, Hungary.
Kelan G TantisiraThe Channing Division of Network Medicine, Department of Medicine, Brigham & Women's hospital & Harvard Medical School, Boston, MA 02115, USA.
Steve TurnerChild Health, University of Aberdeen, Aberdeen, UK.
Marc P van der ScheeDepartment of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
Katia M VerhammeDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Anke H Maitland-van der ZeeDivision of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Funding
Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8MGenes, Home Allergens and Asthma Puerto Rican ChildrenR01HL079966 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2006 to 2010
$3.8MObesity and Asthma Subphenotypes and Underlying Genetic and Genomic PathwaysK08HL125666 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORNO, ERICK · 2015 to 2018
$589kChief Scientist Office CZH/4/418NHLBI NIH HHS K08 HL125666NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL117191
Abstract
aimInternational collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. MATERIALS &
methodsInvestigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.
resultsA total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.
conclusionPiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.
Indexed as
AsthmaPharmacogenomic VariantsResearch DesignAdministration, InhalationAnti-Asthmatic AgentsChildFemaleGenotypeHumansInternational CooperationMalePharmacogeneticsRacial GroupsSurveys and QuestionnairesTreatment OutcomeAnti-Asthmatic Agentsasthmachildrenconsortiumgeneticspharmacogenomicstreatment
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