Evidence map›Paper›PMID 28639489›Full record

ArticlePharmacogenomics2017

Healthcare provider education to support integration of pharmacogenomics in practice: the eMERGE Network experience.

Carolyn R Rohrer Vitek, Noura S Abul-Husn, John J Connolly, Andrea L Hartzler, Terrie Kitchner, Josh F Peterson, Luke V Rasmussen, Maureen E Smith, Sarah Stallings, Marc S Williams and 2 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Pharmacogenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05091879 (Implementation and Evaluation of Preemptive Pharmacogenomics Testing in an Aging Population), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05091879 nacompletednot on this mapstarted 2023, after this paper: background citation

Implementation and Evaluation of Preemptive Pharmacogenomics Testing in an Aging Population

TypeinterventionalSponsorGeisinger ClinicRan2023 to 2026Enrolled66ConditionsPolypharmacy, Pharmacogenomic TestingArmsMultigene pharmacogenomics test
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Pharmacogenetics: Opportunities for theAnnual review of pharmacology and toxicology · 2025
    Review
  9. Review
  10. Article
  11. Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Frontiers in pharmacology · 2022
    Article
  19. Article
  20. The Role of Electronic Health Records in Advancing Genomic Medicine.Annual review of genomics and human genetics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Carolyn R Rohrer VitekCenter for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Noura S Abul-HusnThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
John J ConnollyCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Andrea L HartzlerDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, 98195, USA.
Terrie KitchnerCenter for Human Genetics, Marshfield Clinic Research Institute, Marshfield, WI, 54449, USA.
Josh F PetersonDepartment of Biomedical Informatics & Medicine, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Luke V RasmussenDepartment of Preventive Medicine, Division of Health & Biomedical Informatics, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, USA.
Maureen E SmithDepartment of Medicine, Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, USA.
Sarah StallingsMeharry-Vanderbilt Alliance, Nashville, TN, 37208, USA.
Marc S WilliamsGenomic Medicine Institute, Geisinger Health System, Danville, PA, 17822, USA.
Wendy A WolfDepartment of Pediatrics, Harvard Medical School, Division of Genetics & Genomics, Boston Children's Hospital, Boston, MA, 02115, USA.
Cynthia A ProwsDepartments of Pediatrics and Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229-3039, USA.
Northwestern University · USChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USGeisinger Health System · USHarvard University · USIcahn School of Medicine at Mount Sinai · USMarshfield Clinic · USMayo Clinic · USUniversity of Washington Medical Center · USVanderbilt University Medical Center · US

Funding

Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Variation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4M
The Electronic Medical Records and Genomics (eMERGE) Network Phase III Coordinating Center (U01)U01HG008701 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PETERSON, JOSEPH F. · 2015 to 2019
$7.1M
eMERGE Coordinating Center - Administrative SupplementU01HG006385 · NHGRI · VANDERBILT UNIVERSITY · PI HARRIS, PAUL A. · 2011 to 2014
$5.4M
Biorepository for Genomic Medicine in diverse CommunitiesU01HG006380 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOTTINGER, ERWIN P. · 2011 to 2015
$4.5M
OMOP information model for eMERGE phenotypingU01HG008679 · NHGRI · GEISINGER CLINIC · PI WILLIAMS, MARC S. · 2015 to 2019
$4.4M
Geisinger eGenonic Medicine (GeM) ProgramU01HG006382 · NHGRI · GEISINGER CLINIC · PI CAREY, DAVID J., WILLIAMS, MARC S. · 2011 to 2014
$4.3M
Better Outcomes for Children: Promoting Excellence in Healthcare Genomics to Inform PolicyU01HG008666 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI HARLEY, JOHN BARKER · 2015 to 2019
$4.2M
A Personalized Genomic Medicine Pilot Program Using the NJgene eMERGE ExperienceU01HG006388 · NHGRI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHISHOLM, REX L, SMITH, MAUREEN E · 2011 to 2014
$4.1M
IRIS: Incorporating Research Into SightU01HG006389 · NHGRI · ESSENTIA INSTITUTE OF RURAL HEALTH · PI MCCARTY, CATHERINE ANNE · 2011 to 2014
$4.1M
Genetic Discovery and Application in a Clinical Setting Continuing a PartnershipU01HG006375 · NHGRI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI JARVIK, GAIL PAIRITZ, LARSON, ERIC B · 2011 to 2014
$4.1M
Vanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0M
NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01 HG006828NHGRI NIH HHS U01 HG006830NHGRI NIH HHS U01 HG008657NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008679NHGRI NIH HHS U01 HG008701
6 · The paper itself

Abstract

Ten organizations within the Electronic Medical Records and Genomics Network developed programs to implement pharmacogenomic sequencing and clinical decision support into clinical settings. Recognizing the importance of informed prescribers, a variety of strategies were used to incorporate provider education to support implementation. Education experiences with pharmacogenomics are described within the context of each organization's prior involvement, including the scope and scale of implementation specific to their Electronic Medical Records and Genomics projects. We describe common and distinct education strategies, provide exemplars and share challenges. Lessons learned inform future perspectives. Future pharmacogenomics clinical implementation initiatives need to include funding toward implementing provider education and evaluating outcomes.

Indexed as

Decision Support Systems, ClinicalElectronic Health RecordsHealth PersonnelPharmacogeneticsPrecision MedicineUnited Statesclinical decision supporteducationpharmacogeneticspharmacogenomicspre-emptive testing

Identifiers

PMID28639489
PMCPMC5941709
OpenAlexW2712614606

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.