Observational studyJournal of cachexia, sarcopenia and muscle2017
Muscle mass as a target to reduce fatigue in patients with advanced cancer.
Observational study in Journal of cachexia, sarcopenia and muscle, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06255145 (Assessment of Body Composition, Fatigue, Mobility and Functional Status in Post-Stroke Individuals), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Body Composition, Fatigue, Mobility and Functional Status in Post-Stroke Individuals
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- The Effect of Exercise and Nutritional Interventions on Body Composition in Patients with Advanced or Metastatic Cancer: A Systematic Review.Nutrients · 2022Pooled it
- Impact of a Functional Intervention with Home Follow-Up on Respiratory Symptoms and Functionality in Oncology Patients: A Randomised Clinical Trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Multimodal Physical Exercise and Functional Rehabilitation Program in Oncological Patients with Cancer-Related Fatigue-A Randomized Clinical Trial.International journal of environmental research and public health · 2023Trial
- Muscle contractile properties of cancer patients receiving chemotherapy: Assessment of feasibility and exercise effects.Scandinavian journal of medicine & science in sports · 2020Trial
- Sarcopenia in Oncological Patients Diagnostics, Screening, and Impact on Quality of Life, Fatigue, Handgrip Strength, and Physical Activity (Sarco-Detect Study).Cancer medicine · 2026Article
- Effects of Multicomponent Versus Aerobic Training on Body Composition, Physical Fitness, Psychological Health, and Quality of Life in Cancer Survivors: A 24-Week Randomized Controlled Trial.Sports (Basel, Switzerland) · 2026Article
- Rehabilitation intervention to prevent adverse events related to ADT in patients with metastatic prostate cancer.Future science OA · 2025Article
- Research progress on evaluation methods for skeletal muscle mass assessment in sarcopenia (Review).Oncology letters · 2025Review
- Impact of functional re-education and environmental adaptation in cancer patients with respiratory pathology: Study protocol.PloS one · 2025Article
- Article
- Article
- Longitudinal associations of sedentary behavior and physical activity with body composition in colorectal cancer survivors up to 2 years post treatment.Journal of cancer research and clinical oncology · 2023Article
- Clinical Impacts of Interventions for Physical Activity and Sedentary Behavior on Patients with Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2023Review
- The correlation of muscle quantity and quality between all vertebra levels and level L3, measured with CT: An exploratory study.Frontiers in nutrition · 2023Article
- Review
- Review
- Absence of risk of sarcopenia protects cancer patients from fatigue.European journal of clinical nutrition · 2022Article
- Article
- Multimodal physical exercise and functional rehabilitation program in oncological patients with asthenia. study protocol.BMC nursing · 2021Article
- Intermuscular fat density as a novel prognostic factor in breast cancer patients treated with adjuvant chemotherapy.Breast cancer research and treatment · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF.
methodsA total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue <34). Multiple linear regression analyses were conducted to study the association between SMI and CRF adjusting for relevant confounders.
resultsIn this group of patients with advanced cancer, the median fatigue score was 36 (interquartile range 26-44). A higher SMI on level L3 was significantly associated with less CRF for men (B 0.447, P 0.004) but not for women (B - 0.401, P 0.090). No association between SMI on level T4 and the Functional Assessment of Chronic Illness Therapy-fatigue score was found (n = 82).
conclusionsThe association between SMI and CRF may lead to the suggestion that male patients may be able to reduce fatigue by exercise interventions aiming at an increased muscle mass. In women with advanced cancer, CRF is more influenced by other causes, because it is not significantly related to muscle mass. To further reduce CRF in both men and women with cancer, multifactorial assessments need to be performed in order to develop effective treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.