ArticleEuropean radiology2017
Is multidetector CT-based bone mineral density and quantitative bone microstructure assessment at the spine still feasible using ultra-low tube current and sparse sampling?
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pooled it
- Computed Tomography of the Spine : Systematic Review on Acquisition and Reconstruction Techniques to Reduce Radiation Dose.Clinical neuroradiology · 2023Pooled it
- Radiation dose reduction for CT-guided intrathecal nusinersen administration in adult patients with spinal muscular atrophy.Scientific reports · 2020Trial
- Simulated low-dose multi-detector computed tomography: spatial effects on surrogate parameters of bone strength at the proximal femur.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Design and fabrication of 3D-printed patient-specific soft tissue and bone phantoms for CT imaging.Scientific reports · 2023Article
- Design and fabrication of 3D-printed patient-specific soft tissue and bone phantoms for CT imaging.Research square · 2023Article
- Design and fabrication of 3D-printed patient-specific soft tissue and bone phantoms for CT imaging.medRxiv : the preprint server for health sciences · 2023Article
- Impact of radiation dose reduction and iterative image reconstruction on CT-guided spine biopsies.Scientific reports · 2023Article
- Level-Specific Volumetric BMD Threshold Values for the Prediction of Incident Vertebral Fractures Using Opportunistic QCT: A Case-Control Study.Frontiers in endocrinology · 2022Article
- Hepatic dual-contrast CT imaging: slow triple kVp switching CT with CNN-based sinogram completion and material decomposition.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Beware! Some crucial information is left unattended on our myocardial perfusion scans!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Ultra-low-dose CT versus radiographs for minor spine and pelvis trauma: a Bayesian analysis of accuracy.European radiology · 2021Article
- Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT.Diagnostics (Basel, Switzerland) · 2021Article
- Simulated Annealing-Based Image Reconstruction for Patients With COVID-19 as a Model for Ultralow-Dose Computed Tomography.Frontiers in physiology · 2021Article
- Accuracy, agreement, and reliability of DECT-derived vBMD measurements: an initial ex vivo study.European radiology · 2021Article
- Systematic Evaluation of Low-dose MDCT for Planning Purposes of Lumbosacral Periradicular Infiltrations.Clinical neuroradiology · 2020Article
- Trabecular Architecture and Mechanical Heterogeneity Effects on Vertebral Body Strength.Current osteoporosis reports · 2020Review
- Radiation protection in non-ionizing and ionizing body composition assessment procedures.Quantitative imaging in medicine and surgery · 2020Review
- X-ray-based quantitative osteoporosis imaging at the spine.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Review
- Finite Element Analysis-Based Vertebral Bone Strength Prediction Using MDCT Data: How Low Can We Go?Frontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOsteoporosis diagnosis using multidetector CT (MDCT) is limited to relatively high radiation exposure. We investigated the effect of simulated ultra-low-dose protocols on in-vivo bone mineral density (BMD) and quantitative trabecular bone assessment. MATERIALS AND
methodsInstitutional review board approval was obtained. Twelve subjects with osteoporotic vertebral fractures and 12 age- and gender-matched controls undergoing routine thoracic and abdominal MDCT were included (average effective dose: 10 mSv). Ultra-low radiation examinations were achieved by simulating lower tube currents and sparse samplings at 50%, 25% and 10% of the original dose. BMD and trabecular bone parameters were extracted in T10-L5.
resultsExcept for BMD measurements in sparse sampling data, absolute values of all parameters derived from ultra-low-dose data were significantly different from those derived from original dose images (p<0.05). BMD, apparent bone fraction and trabecular thickness were still consistently lower in subjects with than in those without fractures (p<0.05).
conclusionIn ultra-low-dose scans, BMD and microstructure parameters were able to differentiate subjects with and without vertebral fractures, suggesting osteoporosis diagnosis is feasible. However, absolute values differed from original values. BMD from sparse sampling appeared to be more robust. This dose-dependency of parameters should be considered for future clinical use. KEY POINTS: • BMD and quantitative bone parameters are assessable in ultra-low-dose in vivo MDCT scans. • Bone mineral density does not change significantly when sparse sampling is applied. • Quantitative trabecular bone microstructure measurements are sensitive to dose reduction. • Osteoporosis subjects could be differentiated even at 10% of original dose. • Radiation exposure should be considered when comparing quantitative bone parameters.
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Registered trials
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