ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2017
MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG.
Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 19 citations in OpenAlex.
- A case report of integrating Chinese and Western medicine: A new era in the treatment of late-onset Krabbe disease.Transplantation · 2026Article
- Mycotoxins Co-Exposure Risk Assessment in Coix Seed: Contamination Levels and Safety for Dietary Consumption and Medicinal Intake.Foods (Basel, Switzerland) · 2025Article
- Exploring the Potential of Coix Seeds to Mitigate High Humidity-Induced Gut Inflammation via Microbiota and Metabolite Modulation.Journal of inflammation research · 2025Article
- Analysis of the correlation between the distribution of microorganisms carried byCurrent research in food science · 2025Article
- Cardiovascular protection of YiyiFuzi powder and the potential mechanisms through modulating mitochondria-endoplasmic reticulum interactions.Frontiers in pharmacology · 2024Review
- Inspired by an ancient Chinese Medicine prescription: the modern significance and potential of Yiyi Fuzi Baijiang San in treating diseases.Frontiers in pharmacology · 2024Review
- An Apriori Algorithm-Based Association Analysis of Analgesic Drugs in Chinese Medicine Prescriptions Recorded From Patients With Rheumatoid Arthritis Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Antiosteoporosis Studies of 20 Medicine Food Homology Plants Containing Quercetin, Rutin, and Kaempferol: TCM Characteristics,Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Determination of Differentiating Markers in Coicis Semen From Multi-Sources Based on Structural Similarity Classification Coupled With UPCC-Xevo G2-XS QTOF.Frontiers in pharmacology · 2020Article
- Treatment of Spleen-Deficiency Syndrome With Atractyloside A From Bran-ProcessedFrontiers in pharmacology · 2020Article
- Coix seed improves growth performance and productivity in post-weaning pigs by reducing gut pH and modulating gut microbiota.AMB Express · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoix seed has the functions of fortifying the spleen and inhibiting the dampness. However, it remains unclear which Coix seed compositions is responsible for these functions. Previous investigations have revealed that the main compositions of Coix seed are proteins, polysaccharides, oils and starches. The objectives of this study are to explore which is the most effective compositions in fortifying the spleen and examine how Coix seed works in regulating the water transport on the spleen deficiency and wet dampness (SDWD) rat model. MATERIALS AND
methodsThe rats used were divided into (i) control group, (ii) model group, (iii) decoction group, (iv) protein group, (v) polysaccharide group, (vi) oil group and (vii) starch group. The urine volume, the drinking volume and the water loading index in each group were calculated. Agilent 8*60K array was used for microarray-based gene expression analysis. The differential mRNAs related to the transport activity were screened. qRT-PCR was used to validate the mRNA microarray.
resultsThe results demonstrated that all treatment groups could decrease the dampness of SDWD rats. mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.
conclusionThe compositions of proteins and polysaccharides had the most significant effect in regulating the water transport of SDWD rat model. The contributing mRNA focused on Fabp, Slc and AQP family.
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