ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2017
EFFECT OF YISHENJIANPI RECIPE ON SEMEN QUALITY AND SPERM MITOCHONDRIA IN MICE WITH OLIGOASTHENOZOOSPERMIA INDUCED BY TRIPTERYGIUM GLYCOSIDES.
Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Efficacy of tripterygium glycosides combined with ARB on diabetic nephropathy: a meta-analysis.Bioscience reports · 2020Pooled it
- The Effects of Anthocyanins Added to Semen Diluent on Semen Quality, Semen Antioxidant Capacity, and Sperm Apoptosis in Zi Geese.Animals : an open access journal from MDPI · 2025Article
- The protective effects of active ingredients from acrorus tatarinowii on sperm and their molecular mechanisms.Basic and clinical andrology · 2025Article
- A narrative review of mitochondrial dysfunction and male infertility.Translational andrology and urology · 2024Review
- Molecular mechanism of Cuscutae semen-radix rehmanniae praeparata in relieving reproductive injury of male rats induced with tripterygium wilfordii multiglycosides: A tandem mass tag-based proteomics analysis.Frontiers in pharmacology · 2023Article
- Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review.Health science reports · 2023Article
- Impact of Moriamin Forte on Testicular and Epididymal Damage in Rats with Oligoasthenospermia.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKidney tonifying - spleen strengthening method being one of the modalities for treatment of astheno-oligozoospermia is currently commonly used in the clinical setting. To investigate the mechanism of YiShenJianPi (YSJP) Recipe, used in Traditional Chinese Medicine to benefit "the kidney" and strengthen "the spleen". MATERIALS AND
methodsOligoasthenozoospermia, male BALB/c mice were randomly divided into normal control, disease model, positive control, low-dosage and high-dosage groups. Oligoasthenozoospermia was induced by tripterygium glucosides intragastric administration before treatment started. Through using computer-aided sperm analysis to test the changes in sperm quality, utilizing flow cytometry to test the percentage of sperm with normal mitochondrial transmembrane potential (JC-1 + %), utilizing X-ray microscopy to observe epididymal sperm ultra-microstructure placing special emphasis and photographing the differences in mitochondria of the flagellum region.
resultsCompared with DM, sperm quality of the treated mice was significantly better (P<0.05, respectively). Compared with PC, the LD group had significantly better quality sperms, while the parameters in the HD group were numerically better. Compared with NC, all other groups had significantly lower percentage of sperms with normal mitochondrial membrane potential. In PC, LD and HD groups, the percentage of sperms with normal mitochondrial membrane potential was significantly higher than that of D. The 9+9+2 mitochondrial sheath structure was complete in NC but damaged in DM. In the treatment groups, this structure was fairly clear.
conclusionYSJP improved semen quality with oligoasthenozoospermia by improving sperm mitochondrial membrane potential and restoring sperm mitochondrial ultrastructure.
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