ReviewTheScientificWorldJournal2017
A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma.
Review in TheScientificWorldJournal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature.Turkish archives of otorhinolaryngology · 2022Pooled it
- Review
- Unveiling the Importance of Early Detection of Oral Mucosal Melanoma with Non-Invasive Imaging Techniques.Diagnostics (Basel, Switzerland) · 2026Review
- Case Report: Melanoma of the hard palate presenting initially with gastrointestinal symptoms: the diagnostic pivotal role ofFrontiers in medicine · 2026Article
- From Malaise to Oral Pain: A Case Report on Oral Mucosal Melanoma.Case reports in dentistry · 2026Article
- Sentinel Lymph Node Biopsy in Melanoma: Overview and Updates.International journal of molecular sciences · 2025Review
- The FSIP Family: Roles in Health and Cancer.Cancers · 2025Review
- Multifocal Oral Mucosal Melanoma with an Atypical Clinical Presentation.Dentistry journal · 2025Article
- Primary Malignant Melanoma of the Oropharynx: A Rare Case of a Tonsillar Melanotic Lesion.Cureus · 2025Article
- Melanocortin-1 Receptor Expression as a Marker of Progression in Melanoma.JCO precision oncology · 2024Article
- Review: The Key Factors to Melanomagenesis.Life (Basel, Switzerland) · 2023Review
- Article
- Primary melanoma of the oral cavity: A multi-institutional retrospective analysis in Brazil.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Cutaneous and Mucosal Melanomas of Uncommon Sites: Where Do We Stand Now?Journal of clinical medicine · 2021Review
- A Rare Case of Oral Mucosal Amelanotic Melanoma in a 77-year-old Immunocompromised Man.The Journal of clinical and aesthetic dermatology · 2021Article
- Article
- Epidemiological profile of mucosal melanoma in Brazil.Scientific reports · 2020Article
- Primary Malignant Melanoma of Oral Mucosa - Report of Two Cases.Contemporary clinical dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral mucosal melanoma is an uncommon, usually heavily melanin-pigmented, but occasionally amelanotic aggressive tumour with a poor prognosis. Despite radical surgery, radiotherapy, or chemotherapy, local recurrence and distant metastasis are frequent. Microscopical examination is essential for diagnosis, and routine histological staining must be supplemented by immunohistochemical studies. The aetiology is unknown, the pathogenesis is poorly understood, and the 5-year survival rate rarely exceeds 30%. In most cases, oral mucosal melanoma arises from epithelial melanocytes in the basal layer of the epithelium and less frequently from immature melanocytes arrested in the lamina propria. In both cases the melanocytes undergo malignant transformation, invade deeper tissues, and metastasize to regional lymph nodes and to distant sites. Very rarely metastasis from skin melanoma may give rise to oral mucosal melanoma that may be mistaken for primary oral mucosal melanoma. The pathogenesis of oral mucosal melanoma is complex involving multiple interactions between cytogenetic factors including dysregulation of the cKit signalling pathways, cell cycle, apoptosis, and cell-to-cell interactions on the one hand and melanin itself, melanin intermediates, and local microenvironmental agents regulating melanogenesis on the other hand. The detailed mechanisms that initiate the malignant transformation of oral melanocytes and thereafter sustain and promote the process of melanomagenesis are unknown.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.