ArticleFrontiers in cellular and infection microbiology2017
Increased Zinc Availability Enhances Initial Aggregation and Biofilm Formation of
Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Prolonged zinc exposure modulates biofilm metabolic activity and conjugation in Enterococcus faecalis.BMC microbiology · 2026Article
- Zinc and hydroxyapatite co-localize during in vitro E. coli biofilms mineralization.Scientific reports · 2026Article
- Protective antigens hidden in the bovine Clostridium vaccine.Frontiers in immunology · 2026Article
- Structure, Function, and Regulation of LytA: TheMicroorganisms · 2025Review
- Metabolic adaptations of Escherichia coli to extended zinc exposure: insights into tricarboxylic acid cycle and trehalose synthesis.BMC microbiology · 2024Article
- Metal-regulated antibiotic resistance and its implications for antibiotic therapy.Microbial biotechnology · 2024Review
- Zinc effects on bacteria: insights frommSystems · 2023Article
- Calorimetric analysis of AdcR and its interactions with zinc(II) and DNA.Journal of inorganic biochemistry · 2023Article
- S100A9 is indispensable for survival of pneumococcal pneumonia in mice.PLoS pathogens · 2023Article
- Comparative Analysis of Physical and Chemical Properties of Differently Obtained Zn-Methionine Chelate with Proved Antibiofilm Properties (Part II).Pharmaceutics · 2023Article
- Anti-Virulence Strategy of Novel Dehydroabietic Acid Derivatives: Design, Synthesis, and Antibacterial Evaluation.International journal of molecular sciences · 2023Article
- Wogonin attenuates the pathogenicity of Streptococcus pneumoniae by double-target inhibition of Pneumolysin and Sortase A.Journal of cellular and molecular medicine · 2023Article
- Metal Homeostasis in Pathogenic Streptococci.Microorganisms · 2022Review
- Pneumococcal surface adhesion A protein (PsaA) interacts with human Annexin A2 on airway epithelial cells.Virulence · 2021Article
- Role of different types of nanomaterials against diagnosis, prevention and therapy of COVID-19.Sustainable cities and society · 2021Review
- Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Hemoglobin Induces Early and Robust Biofilm Development inInfection and immunity · 2021Article
- Article
- Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review).International journal of molecular medicine · 2020Review
- N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine, a zinc chelator, inhibits biofilm and hyphal formation in Trichosporon asahii.BMC research notes · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Bacteria growing within biofilms are protected from antibiotics and the immune system. Within these structures, horizontal transfer of genes encoding virulence factors, and promoting antibiotic resistance occurs, making biofilms an extremely important aspect of pneumococcal colonization and persistence. Identifying environmental cues that contribute to the formation of biofilms is critical to understanding pneumococcal colonization and infection. Iron has been shown to be essential for the formation of pneumococcal biofilms; however, the role of other physiologically important metals such as copper, zinc, and manganese has been largely neglected. In this study, we investigated the effect of metals on pneumococcal aggregation and early biofilm formation. Our results show that biofilms increase as zinc concentrations increase. The effect was found to be zinc-specific, as altering copper and manganese concentrations did not affect biofilm formation. Scanning electron microscopy analysis revealed structural differences between biofilms grown in varying concentrations of zinc. Analysis of biofilm formation in a mutant strain lacking the peroxide-generating enzyme pyruvate oxidase, SpxB, revealed that zinc does not protect against pneumococcal H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.