ArticleBrain and behavior2017
Abnormal amplitude of low-frequency fluctuations and functional connectivity of resting-state functional magnetic resonance imaging in patients with leukoaraiosis.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Visualization Analysis of Acupuncture for the Treatment of Insomnia: A Scoping Literature Review Based on an International Database.Medical acupuncture · 2025Review
- Dynamic alterations in the amplitude of low-frequency fluctuation in patients with cerebral small vessel disease.Frontiers in molecular neuroscience · 2023Article
- Low-frequency oscillations in the brain show differential regional associations with severity of cerebral small vessel disease: a systematic review.Frontiers in neuroscience · 2023Review
- Magnetic resonance imaging of white matter in Alzheimer's disease: a global bibliometric analysis from 1990 to 2022.Frontiers in neuroscience · 2023Review
- Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment.Frontiers in neurology · 2022Review
- White matter of perinatally HIV infected older youths shows low frequency fluctuations that may reflect glial cycling.Scientific reports · 2021Article
- Thalamocortical Functional Connectivity in Patients With White Matter Hyperintensities.Frontiers in aging neuroscience · 2021Article
- White-Matter Hyperintensity Load and Differences in Resting-State Network Connectivity Based on Mild Cognitive Impairment Subtype.Frontiers in aging neuroscience · 2021Article
- Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity.Frontiers in aging neuroscience · 2021Article
- Associations Between Altered Cerebral Activity Patterns and Psychosocial Disorders in Patients With Psychogenic Erectile Dysfunction: A Mediation Analysis of fMRI.Frontiers in psychiatry · 2020Article
- Cerebrovascular Reactivity Mapping Without Gas Challenges: A Methodological Guide.Frontiers in physiology · 2020Review
- Resting state connectivity within the basal ganglia and gait speed in older adults with cerebral small vessel disease and locomotor risk factors.NeuroImage. Clinical · 2020Article
- Assessment of cerebrovascular reserve impairment using the breath-holding index in patients with leukoaraiosis.Neural regeneration research · 2019Article
- Altered static and dynamic functional network connectivity in Alzheimer's disease and subcortical ischemic vascular disease: shared and specific brain connectivity abnormalities.Human brain mapping · 2019Article
- Low-Frequency Fluctuations Amplitude Signals Exhibit Abnormalities of Intrinsic Brain Activities and Reflect Cognitive Impairment in Leukoaraiosis Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Abnormal Interactions of the Salience Network, Central Executive Network, and Default-Mode Network in Patients With Different Cognitive Impairment Loads Caused by Leukoaraiosis.Frontiers in neural circuits · 2019Article
- Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis.Medical science monitor : international medical journal of experimental and clinical research · 2018Review
- Abnormal amplitude of low-frequency fluctuations and functional connectivity of resting-state functional magnetic resonance imaging in patients with leukoaraiosis.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to investigate the cerebral function deficits in patients with leukoaraiosis (LA) and the correlation with white matter hyperintensity (WMH) using functional MRI (fMRI) technology. MATERIALS AND
methodsTwenty-eight patients with LA and 30 volunteers were enrolled in this study. All patients underwent structural MRI and resting-state functional MRI (rs-fMRI) scanning. The amplitude of low-frequency fluctuations (ALFF) of rs-fMRI signals for the two groups was compared using two-sample t tests. A one-sample
resultsCompared with the control group, the LA group showed a significant decrease in the ALFF in the left parahippocampal gyrus (PHG) and an increased ALFF in the left inferior semi-lunar lobule and right superior orbital frontal gyrus (SOFG). The patients with LA showed an increased functional connectivity between the right insular region and the right SOFG and between the right calcarine cortex and the left PHG. After the effects of age, gender, and years of education were corrected as covariates, the functional connectivity strength of the right insular and the right SOFG showed close correlations with the Fazekas scores.
conclusionOur results enhance the understanding of the pathomechanism of LA. Leukoaraiosis is associated with widespread cerebral function deficits, which show a close correlation with WMH and can be measured by rs-fMRI.
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