ArticleBrain and behavior2017
Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mapping motor and extra-motor gray and white matter changes in ALS: a comprehensive review of MRI insights.Neuroradiology · 2025Review
- Adapting to Changes in Communication: The Orbitofrontal Cortex in Language and Speech Processing.Brain sciences · 2024Review
- Understanding depression with amyotrophic lateral sclerosis: a short assessment of facts and perceptions.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Feasibility and diagnostics of the Frontal Assessment Battery (FAB) in amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Amyotrophic lateral sclerosis care in Saudi Arabia: A survey of providers' perceptions.Brain and behavior · 2020Article
- Multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis.Neurology · 2020Article
- Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis.Brain and behavior · 2017Article
- Non-Motor Features of Amyotrophic Lateral Sclerosis: A Clinic-based Study.Annals of Indian Academy of NeurologyArticle
- Impaired executive functioning mediates the association between aging and deterministic sequence learning.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognitionArticle
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the potential utility of the frontal assessment battery (FAB) in assessing cognitive impairments in amyotrophic lateral sclerosis (ALS), we investigated the association between the FAB score and regional gray matter volume, and ascertained whether the regional brain alterations related to cognitive impairments occur in relatively mild stage of ALS. MATERIALS AND
methodsTwenty-four ALS patients with a Mini-Mental State Examination score of >23, a normal score on the Self-Rating Depression Scale, little or no disturbance in speech and handling utensils on the ALS Functional Rating Scale (ALSFRS), and normal measures on respiratory tests (respiratory function test and arterial blood gas analysis), and two age-matched normal control groups (one for FAB assessment and the other for brain morphometry) underwent FAB testing and structural magnetic resonance imaging. We applied voxel-based morphometry to investigate the relationship between the FAB score and regional brain alteration, and assessed the relationship between the altered regional brain volume and ALSFRS or respiratory tests.
resultsFrontal assessment battery scores were significantly lower in ALS patients than in normal controls. Volume reduction in the right orbitofrontal gyrus in ALS was correlated with a lower FAB score. There was no correlation between the right orbitofrontal gyrus volume and ALSFRS or respiratory tests.
conclusionsThe results suggest that the FAB is an adequate tool for detecting cognitive impairments related to frontal lobe pathology in the relatively mild stage of ALS, independent of physical dysfunctions.
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