Evidence map›Paper›PMID 28638479›Full record

ArticleTheranostics2017

Should Low Molecular Weight PSMA Targeted Ligands Get Bigger and Use Albumin Ligands for PSMA Targeting?

Steve S Huang, Warren D W Heston

Open access · goldAbstract readEditorialComment
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

  • Comment on
    2017
5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Steve S HuangCancer Biology Department Lerner Research Institute, Cleveland Clinic Cleveland OH.
Warren D W HestonCancer Biology Department Lerner Research Institute, Cleveland Clinic Cleveland OH.
Cleveland Clinic Lerner College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate Specific Membrane Antigen (PSMA) is strongly expressed in prostate cancer. Recently a number of low-molecular-weight inhibitors have demonstrated excellent PSMA targeting activity for both imaging as well as Lutecium-177 radiotherapy in human trials. The paper by Choy et al raises the question of whether we can further increase the effectiveness of PSMA targeted therapy by adding an albumin-binding entity to low-molecular-weight agents.

Indexed as

Glutamate Carboxypeptidase IIProstatic NeoplasmsAlbuminsAmidesAnimalsAntigens, SurfaceHumansLigandsMaleMiceMolecular WeightPhosphoric AcidsTissue DistributionAlbuminsAmidesAntigens, SurfaceGlutamate Carboxypeptidase IILigandsphosphoramidic acidPhosphoric Acids

Identifiers

PMID28638479
PMCPMC5479280
OpenAlexW2610481889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.