Evidence map›Paper›PMID 28638478›Full record

ArticleTheranostics2017

Cindy J Choy, Xiaoxi Ling, Jonathan J Geruntho, Sophia K Beyer, Joseph D Latoche, Beatrice Langton-Webster, Carolyn J Anderson, Clifford E Berkman

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 129 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The development ofEJNMMI radiopharmacy and chemistry · 2024
    Article
  14. Article
  15. A PSMA-targeted doxorubicin small-molecule drug conjugate.Bioorganic & medicinal chemistry letters · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Preclinical Evaluation of a New Series of Albumin-BindingMolecules (Basel, Switzerland) · 2023
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cindy J ChoyCancer Targeted Technology, Woodinville, WA.
Xiaoxi LingDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15203.
Jonathan J GerunthoDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15203.
Sophia K BeyerCancer Targeted Technology, Woodinville, WA.
Joseph D LatocheDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15203.
Beatrice Langton-WebsterCancer Targeted Technology, Woodinville, WA.
Carolyn J AndersonDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15203.
Clifford E BerkmanCancer Targeted Technology, Woodinville, WA.
Cancer Targeted Technology (United States) · USUniversity of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Clinical Evaluation of an Innovative PSMA-targeted Radiotherapy, CTT1403, in Prostate CancerR44CA239461 · NCI · CANCER TARGETED TECHNOLOGY, LLC · PI LANGTON-WEBSTER, BEATRICE · 2019 to 2021
$3.2M
Clinical Evaluation of a Novel Prostate Cancer PET DiagnosticR44CA192451 · NCI · CANCER TARGETED TECHNOLOGY, LLC · PI LANGTON-WEBSTER, BEATRICE · 2015 to 2016
$2.0M
Development of a novel PET imaging agent for prostate cancerR44CA153481 · NCI · CANCER TARGETED TECHNOLOGY, LLC · PI LANGTON-WEBSTER, BEATRICE · 2010 to 2011
$1.5M
Development of a PSMA-Targeted Small-Molecule Drug Conjugate for Prostate CancerR43CA221511 · NCI · CANCER TARGETED TECHNOLOGY, LLC · PI LANGTON-WEBSTER, BEATRICE · 2018 to 2018
$300k
NCI NIH HHS HHSN261201500074CNCI NIH HHS P30 CA047904NCI NIH HHS R43 CA221511NCI NIH HHS R44 CA153481NCI NIH HHS R44 CA192451NCI NIH HHS R44 CA239461
6 · The paper itself

Abstract

Prostate-specific membrane antigen (PSMA) continues to be an active biomarker for small-molecule PSMA-targeted imaging and therapeutic agents for prostate cancer and various non-prostatic tumors that are characterized by PSMA expression on their neovasculature. One of the challenges for small-molecule PSMA inhibitors with respect to delivering therapeutic payloads is their rapid renal clearance. In order to overcome this pharmacokinetic challenge, we outfitted a

Indexed as

AlbuminsAmidesAnimalsAntigens, SurfaceAntineoplastic AgentsCell Line, TumorDisease Models, AnimalGlutamate Carboxypeptidase IIHeterograftsHumansLutetiumMaleMiceMice, NudePhosphoric AcidsProstatic NeoplasmsAlbuminsAmidesAntigens, SurfaceAntineoplastic AgentsFOLH1 protein, humanGlutamate Carboxypeptidase IILutetiumLutetium-177phosphoramidic acidPhosphoric AcidsRadioisotopes177LualbuminphosphoramidatePSMAradiotherapy.

Identifiers

PMID28638478
PMCPMC5479279
OpenAlexW2611673620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.