Evidence map›Paper›PMID 28638473›Full record

ArticleTheranostics2017

Rapid fluorescence imaging of spinal cord following epidural administration of a nerve-highlighting fluorophore.

Wanguo Liu, Rui Gu, Qingsan Zhu, Chunsheng Xiao, Lanfeng Huang, Xinming Zhuang, Jingzhe Zhang, Lidi Liu, Ben Ma, Huailin Yang and 5 more

Abstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Nanocarrier-mediated drug delivery systems for spinal cord injury treatment.Frontiers in bioengineering and biotechnology · 2025
    Review
  2. Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024
    Review
  3. Review
  4. Review
  5. Advances in optical molecular imaging for neural visualization.Frontiers in bioengineering and biotechnology · 2023
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wanguo LiuDepartment of Orthopaedic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.
Rui GuDepartment of Orthopaedic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.
Qingsan ZhuDepartment of Orthopaedic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.
Chunsheng XiaoKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Lanfeng HuangDepartment of Orthopaedic Surgery, The Second Hospital, JilinUniversity, Changchun, China.
Xinming ZhuangDepartment of Orthopaedic Surgery, The First Hospital, JilinUniversity, Changchun, China.
Jingzhe ZhangDepartment of Orthopaedic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.
Lidi LiuDepartment of Orthopaedic Surgery, The First Hospital, JilinUniversity, Changchun, China.
Ben MaDepartment of Orthopaedic Surgery, Jinhua Central Hospital, Zhejiang University, Jinhua, China.
Huailin YangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Jianchao MaDepartment of Orthopaedic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.
Zhipeng HuKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Chenglin TangDepartment of Orthopaedic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.
Shuhua ZhaoDepartment of Occupational and Environmental Health, Public Health School, Jilin University, Changchun, China.
Xuesi ChenKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iatrogenic spinal cord injury (SCI) is the most devastating complication of spine surgery, which usually results in permanent and serious disabilities of patients. Improvement of the visualization and discrimination of the spinal cord is critical for accuracy and safety during surgery; however, to date, there is no suitable technology to fulfill this clinical need. Here, we first show an efficient and rapid fluorescence imaging of the spinal cord in rabbit by epidural administration of a nerve-highlighting fluorophore,

Indexed as

AnimalsFluorescent DyesInjections, EpiduralIntravital MicroscopyOptical ImagingRabbitsSpinal CordTime FactorsFluorescent Dyescerebrospinal fluidepidural administrationfluorescenceimage-guided surgeryspinal cordspinal cord injury.

Identifiers

PMID28638473
PMCPMC5479274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.