Evidence map›Paper›PMID 28638384›Full record

ArticleFrontiers in immunology2017

Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes

Shuang Geng, Yiwei Zhong, Xiaoyu Zhou, Gan Zhao, Xiaoping Xie, Yechun Pei, Hu Liu, Huiyuan Zhang, Yan Shi, Bin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuang GengKey Laboratory of Medical Molecular Virology of MOH and MOE, Fudan University Shanghai Medical College, Shanghai, China.
Yiwei ZhongKey Laboratory of Medical Molecular Virology of MOH and MOE, Fudan University Shanghai Medical College, Shanghai, China.
Xiaoyu ZhouKey Laboratory of Medical Molecular Virology of MOH and MOE, Fudan University Shanghai Medical College, Shanghai, China.
Gan ZhaoKey Laboratory of Medical Molecular Virology of MOH and MOE, Fudan University Shanghai Medical College, Shanghai, China.
Xiaoping XieState Key Laboratory for Agro-Biotechnology, China Agricultural University, Beijing, China.
Yechun PeiState Key Laboratory for Agro-Biotechnology, China Agricultural University, Beijing, China.
Hu LiuState Key Laboratory for Agro-Biotechnology, China Agricultural University, Beijing, China.
Huiyuan ZhangState Key Laboratory for Agro-Biotechnology, China Agricultural University, Beijing, China.
Yan ShiTsinghua-Peking Center for Life Sciences; Institute for Immunology, School of Medicine, Tsinghua University, Beijing, China.
Bin WangKey Laboratory of Medical Molecular Virology of MOH and MOE, Fudan University Shanghai Medical College, Shanghai, China.

Funding

Adjuvants' mechanismsR01AI098995 · NIAID · UNIVERSITY OF CALGARY · PI SHI, YAN · 2012 to 2016
$1.0M
Alum's adjuvanticityR21AI089963 · NIAID · UNIVERSITY OF CALGARY · PI SHI, YAN · 2010 to 2011
$295k
NIAID NIH HHS R01 AI098995NIAID NIH HHS R21 AI089963
6 · The paper itself

Abstract

Regulatory T cells (Tregs) restrict overexuberant lymphocyte activation. While close proximity between Tregs and their suppression targets is important for optimal inhibition, and literature indicates that draining lymph nodes (LNs) may serve as a prime location for the suppression, signaling details orchestrating this event are not fully characterized. Using a protocol to enable peripheral generation of inducible antigen-specific Tregs (asTregs) to control allergen-induced asthma, we have identified an antigen-specific mechanism that locks asTregs within hilar LNs which in turn suppresses airway inflammation. The suppressive asTregs, upon antigen stimulation in the LN, downregulate sphingosine-1-phosphate receptor 1 egress receptor expression. These asTregs in turn mediate the downregulation of the same receptor on incoming effector T cells. Therefore, asTregs and effector T cells are locked in these draining LNs for prolonged interactions. Disruption of individual steps of this retention sequence abolishes the inflammation controlled by asTregs. Collectively, this study identifies a new requirement of spatial congregation with their suppression targets essential for asTreg functions and suggests therapeutic programs

Indexed as

airway inflammationantigen specific suppressionegresshilar lymph nodeinducible regulatory T cellS1p1

Identifiers

PMID28638384
PMCPMC5461288

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.