ArticleFrontiers in microbiology2017
Interactions between Food Additive Silica Nanoparticles and Food Matrices.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Toxicity of fluorescent silica nanoparticles in brine shrimp and their implications as food ingestion markers.Scientific reports · 2025Article
- Impact of Milk on the Behavior and Toxicity of Nanosized SiOACS omega · 2025Article
- Nanotechnology for Mitigating Biological Cross-Contamination in Meat Processing.Journal of food science · 2025Review
- Silicon Dioxide Nanoparticles Affect the In Vitro Digestion of Sodium Caseinate but Not the Formation and Functionality of Bioactive Peptides.Food science & nutrition · 2025Article
- Evaluating the Effects of Chronic Oral Exposure to the Food Additive Silicon Dioxide on Oral Tolerance Induction and Food Sensitivities in Mice.Environmental health perspectives · 2024Article
- Correct labelling? A full analytical pathway for silica and titania particles in food products.Current research in food science · 2024Article
- Biocorona on Iron Oxide Nanoparticles in a Complex Biotechnological Environment: Analysis of Proteins, Lipids, and Carbohydrates.Small science · 2023Article
- Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments.Particle and fibre toxicology · 2023Article
- Fluorescent silica nanoparticles as an internal marker in fruit flies and their effects on survivorship and fertility.Scientific reports · 2022Article
- Preparation of Poly(acrylic acid-Polymers · 2022Article
- Characterization and Determination of Nanoparticles in Commercial Processed Foods.Foods (Basel, Switzerland) · 2021Article
- Establishment of a standardized dietary model for nanoparticles oral exposure studies.Food science & nutrition · 2021Article
- Toxicity of combined exposure of ZnO nanoparticles (NPs) and myricetin to Caco-2 cells: changes of NP colloidal aspects, NP internalization and the apoptosis-endoplasmic reticulum stress pathway.Toxicology research · 2019Article
- Food Additive Titanium Dioxide and Its Fate in Commercial Foods.Nanomaterials (Basel, Switzerland) · 2019Article
- A hydrofluoric acid-free method to dissolve and quantify silica nanoparticles in aqueous and solid matrices.Scientific reports · 2019Article
- Protein Food Matrix⁻ZnO Nanoparticle Interactions Affect Protein Conformation, but May not Be Biological Responses.International journal of molecular sciences · 2018Article
- Sol-gel Silica Nanoparticles in Medicine: A Natural Choice. Design, Synthesis and Products.Molecules (Basel, Switzerland) · 2018Review
- Article
- In Vitro and In Vivo Short-Term Pulmonary Toxicity of Differently Sized Colloidal Amorphous SiO₂.Nanomaterials (Basel, Switzerland) · 2018Article
- Effects of Interactions between ZnO Nanoparticles and Saccharides on Biological Responses.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles (NPs) have been widely utilized in the food industry as additives with their beneficial characteristics, such as improving sensory property and processing suitability, enhancing functional and nutritional values, and extending shelf-life of foods. Silica is used as an anti-caking agent to improve flow property of powered ingredients and as a carrier for flavors or active compounds in food. Along with the rapid development of nanotechnology, the sizes of silica fall into nanoscale, thereby raising concerns about the potential toxicity of nano-sized silica materials. There have been a number of studies carried out to investigate possible adverse effects of NPs on the gastrointestinal tract. The interactions between NPs and surrounding food matrices should be also taken into account since the interactions can affect their bioavailability, efficacy, and toxicity. In the present study, we investigated the interactions between food additive silica NPs and food matrices, such as saccharides, proteins, lipids, and minerals. Quantitative analysis was performed to determine food component-NP corona using HPLC, fluorescence quenching, GC-MS, and ICP-AES. The results demonstrate that zeta potential and hydrodynamic radius of silica NPs changed in the presence of all food matrices, but their solubility was not affected. However, quantitative analysis on the interactions revealed that a small portion of food matrices interacted with silica NPs and the interactions were highly dependent on the type of food component. Moreover, minor nutrients could also affect the interactions, as evidenced by higher NP interaction with honey rather than with a simple sugar mixture containing an equivalent amount of fructose, glucose, sucrose, and maltose. These findings provide fundamental information to extend our understanding about the interactions between silica NPs and food components and to predict the interaction effect on the safety aspects of food-grade NPs.
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