Evidence map›Paper›PMID 28638351›Full record

ReviewFrontiers in psychiatry2017

Transcranial Direct Current Stimulation: Considerations for Research in Adolescent Depression.

Jonathan C Lee, Charles P Lewis, Zafiris J Daskalakis, Paul E Croarkin

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03368469 (A Pilot Study of the Tolerability and Efficacy of Transcranial Direct Current Stimulation), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03368469 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

A Pilot Study of the Tolerability and Efficacy of Transcranial Direct Current Stimulation (tDCS) in Children and Adolescents With Epilepsy and Comorbid Depression

TypeinterventionalSponsorMayo ClinicRan2018 to 2019Enrolled0ConditionsDepressive Disorder, Generalized EpilepsyArmstranscranial direct current stimulation
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Neuroethics of Neuromodulation: An Update.Current opinion in biomedical engineering · 2018
    Article
  11. A pilot study of GABAPsychiatry research. Neuroimaging · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jonathan C LeeTemerty Centre for Therapeutic Brain Intervention, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Charles P LewisMayo Clinic Depression Center, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.
Zafiris J DaskalakisTemerty Centre for Therapeutic Brain Intervention, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Paul E CroarkinMayo Clinic Depression Center, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.
Mayo Clinic in Arizona · USUniversity of Toronto · CA

Funding

Glutamate Probes in Adolescent DepressionK23MH100266 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2014 to 2017
$685k
NIMH NIH HHS K23 MH100266
6 · The paper itself

Abstract

Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression. Transcranial direct current stimulation (tDCS) applies a low-intensity, continuous current that alters cortical excitability. While this modality does not elicit action potentials, it is thought to manipulate neuronal activity and neuroplasticity. Specifically, tDCS may modulate

Indexed as

adolescent depressionneurostimulationnon-invasive brain stimulationtranscranial current stimulationtranscranial direct current stimulation

Identifiers

PMID28638351
PMCPMC5461263
OpenAlexW2623038695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.