Evidence map›Paper›PMID 28638231›Full record

ArticleWorld journal of gastroenterology2017

Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer.

Jun Yao, Lu-Lin Zhang, Xu-Mei Huang, Wen-Yao Li, She-Gan Gao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  5. Pleiotrophin drives a prometastatic immune niche in breast cancer.The Journal of experimental medicine · 2023
    Article
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  7. Article
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  10. Review
  11. Review
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  14. Article
  15. Pleiotrophin: Activity and mechanism.Advances in clinical chemistry · 2020
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jun YaoJun Yao, Lu-Lin Zhang, Wen-Yao Li, She-Gan Gao, Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Lu-Lin ZhangJun Yao, Lu-Lin Zhang, Wen-Yao Li, She-Gan Gao, Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Xu-Mei HuangJun Yao, Lu-Lin Zhang, Wen-Yao Li, She-Gan Gao, Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Wen-Yao LiJun Yao, Lu-Lin Zhang, Wen-Yao Li, She-Gan Gao, Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
She-Gan GaoJun Yao, Lu-Lin Zhang, Wen-Yao Li, She-Gan Gao, Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
The University of Texas Southwestern Medical Center · USHenan University of Science and Technology · CNSouthwestern Medical Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo detect the expression of pleiotrophin (PTN) and N-syndecan in pancreatic cancer and analyze their association with tumor progression and perineural invasion (PNI).

methodsAn orthotopic mouse model of pancreatic cancer was created by injecting tumor cells subcapsularly in a root region of the pancreas beneath the spleen. Pancreatic cancer tissues were taken from 36 mice that survived for more than 90 d. PTN and N-syndecan proteins were detected by immunohistochemistry and analyzed for their correlation with pathological features, PNI, and prognosis.

resultsThe expression rates of PTN and N-syndecan proteins were 66.7% and 61.1%, respectively, in cancer tissue. PTN and N-syndecan expression was associated with PNI (

conclusionHigh PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and PNI in the orthotopic mouse model of pancreatic cancer.

Indexed as

AnimalsBiomarkers, TumorCarrier ProteinsCell Line, TumorCytokinesDisease ProgressionHumansImmunohistochemistryKaplan-Meier EstimateMaleMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessPancreasPancreatic NeoplasmsBiomarkers, TumorCarrier ProteinsCytokinespleiotrophinSDC3 protein, humanSyndecan-3N-syndecanPancreatic cancerPerineural invasionPleiotrophin

Identifiers

PMID28638231
PMCPMC5467077
OpenAlexW2623055908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.