Evidence map›Paper›PMID 28638124›Full record

ArticleScientific reports2017

Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration.

Andrew Campbell, Jessica M Hogestyn, Christopher J Folts, Brittany Lopez, Christoph Pröschel, David Mock, Margot Mayer-Pröschel

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew CampbellDepartment of Biomedical Genetics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 633, NY, 14642, USA.
Jessica M HogestynDepartment of Biomedical Genetics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 633, NY, 14642, USA.
Christopher J FoltsDivision of Newborn Medicine, Boston Children's Hospital/Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Brittany LopezDepartment of Biomedical Genetics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 633, NY, 14642, USA.
Christoph PröschelDepartment of Biomedical Genetics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 633, NY, 14642, USA.
David MockDepartment of Biomedical Genetics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 633, NY, 14642, USA. David_mock@urmc.rochester.edu.
Margot Mayer-PröschelDepartment of Biomedical Genetics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 633, NY, 14642, USA. Margot_mayer-proschel@urmc.rochester.edu.
University of Rochester · USBoston Children's Hospital · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
New animal model to study the impact of latent human herpesvius 6 (HHV6) infection on the remyelination processR03NS103124 · NINDS · UNIVERSITY OF ROCHESTER · PI MAYER-PROSCHEL, MARGOT · 2017 to 2018
$154k
NIEHS NIH HHS P30 ES001247NINDS NIH HHS R03 NS103124
6 · The paper itself

Abstract

Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may contribute to inadequate myelin repair after injury.

Indexed as

Cell MovementVirus LatencyCells, CulturedDemyelinating DiseasesHerpesvirus 6, HumanHumansOligodendrocyte Precursor CellsViral ProteinsViral Proteins

Identifiers

PMID28638124
PMCPMC5479784
OpenAlexW2626952338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.