Evidence map›Paper›PMID 28638116›Full record

ArticleScientific reports2017

Laser-ultrasonic delivery of agents into articular cartilage.

Heikki J Nieminen, Gonçalo Barreto, Mikko A Finnilä, Alejandro García-Pérez, Ari Salmi, Sanjeev Ranjan, Kari K Eklund, Kenneth P H Pritzker, Simo Saarakkala, Edward Hæggström

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Heikki J NieminenElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland. heikki.j.nieminen@aalto.fi.ORCID 0000-0001-6084-1272
Gonçalo BarretoOrton Orthopaedic Hospital and Research Institute, Invalid Foundation, Helsinki, Finland.
Mikko A FinniläResearch Group of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Alejandro García-PérezElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Ari SalmiElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Sanjeev RanjanLaboratory of Radiochemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland.
Kari K EklundDepartment of Rheumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-5870-4663
Kenneth P H PritzkerDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Simo SaarakkalaResearch Group of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Edward HæggströmElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIMount Sinai Hospital · CAOulu University Hospital · FIUniversity of Eastern Finland · FI

Funding

European Research Council 336267
6 · The paper itself

Abstract

Research is ongoing to develop drug therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries. However, means to deliver drug to localized AC lesions are highly limited and not clinically available. This study investigates the capability of laser ultrasound (laser-induced plasma sound source) to deliver agents (methylene blue, MB, in PBS) into bovine AC. Treatment samples (n = 10) were immersed in MB solution simultaneously with LU exposure, while adjacent control 1 tissue (n = 10) was pre-treated with LU followed by immersion in MB and adjacent control 2 tissue (n = 10) was only immersed in MB. AC exposed (n = 22) or not exposed (n = 27) to LU were characterized for anomalies in structure, composition, viability or RNA expression. Optically detected MB content was significantly (p < 0.01) higher in treatment samples up to a depth of 500 µm from AC surface as compared to controls. No major unwanted short-term effects on AC structure, proteoglycan or collagen contents, chondrocyte viability or RNA expression levels were detected. In conclusion, LU can deliver agents into AC without major short-term concerns on safety. LU could reveal new strategies for the development of localized drug therapies in AC.

Indexed as

LasersAnimalsCartilage, ArticularCattleDrug Delivery SystemsGene Expression RegulationHumansMethylene BlueOsteoarthritisRNAUltrasonographyMethylene BlueRNA

Identifiers

PMID28638116
PMCPMC5479804
OpenAlexW2626357616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.