Evidence map›Paper›PMID 28637884›Full record

ArticleThe Journal of experimental medicine2017

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.

Antje Heit, Frank Schmitz, Sarah Gerdts, Britta Flach, Miranda S Moore, Jonathan A Perkins, Harlan S Robins, Alan Aderem, Paul Spearman, Georgia D Tomaras and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 124 citations in OpenAlex.

  1. Trial
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  3. Protein/AS01Cell reports. Medicine · 2021
    Trial
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  6. Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026
    Review
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Antje HeitVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Frank SchmitzCenter for Infectious Disease Research, Seattle, WA.
Sarah GerdtsVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Britta FlachVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Miranda S MooreVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Jonathan A PerkinsDepartment of Otolaryngology, University of Washington, Seattle, WA.ORCID http://orcid.org/0000-0003-0181-3997
Harlan S RobinsPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Alan AderemCenter for Infectious Disease Research, Seattle, WA.ORCID http://orcid.org/0000-0003-4031-5499
Paul SpearmanPediatric Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH.
Georgia D TomarasDuke Human Vaccine Institute, Duke University, Durham, NC.
Stephen C De RosaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
M Juliana McElrathVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.ORCID http://orcid.org/0000-0003-2276-7117
Fred Hutch Cancer Center · USCenter for Infectious Disease Research · USUniversity of Washington · USCincinnati Children's Hospital Medical Center · USDuke University · USSeattle Children's Hospital · US

Funding

LOC: HIV Vaccine Trials NetworkUM1AI068614 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Dan H. Barouch, Lawrence Corey · 2011 to 2026
$1175.6M
LC: HIV Vaccine Trials NetworkUM1AI068618 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Margaret Juliana McElrath · 2011 to 2026
$483.6M
NIAID NIH HHS UM1 AI068614NIAID NIH HHS UM1 AI068618
6 · The paper itself

Abstract

Germinal center T follicular helper cells (GCTfh) in lymphatic tissue are critical for B cell differentiation and protective antibody induction, but whether GCTfh establish clonal derivatives as circulating memory T cells is less understood. Here, we used markers expressed on GCTfh, CXCR5, PD1, and ICOS, to identify potential circulating CXCR5

Indexed as

AdolescentAIDS VaccinesCD4-Positive T-LymphocytesChildChild, PreschoolClone CellsFlow CytometryGerminal CenterHumansImmunologic MemoryImmunophenotypingPalatine TonsilProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellReceptors, CXCR5Reverse Transcriptase Polymerase Chain ReactionAIDS VaccinesCXCR5 protein, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellReceptors, CXCR5

Identifiers

PMID28637884
PMCPMC5502430
OpenAlexW2644728868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.