ArticleThe Journal of experimental medicine2017
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- Inflammation as a central driver in AML pathogenesis and therapy resistance.Science China. Life sciences · 2026Review
- TLR2 agonism suppresses myeloid leukemogenesis by reprogramming leukemia stem cells.Blood advances · 2025Article
- In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy.Cancer cell · 2024Article
- Leukemic Stem Cells and Hematological Malignancies.International journal of molecular sciences · 2024Review
- Leukemic stem cells and therapy resistance in acute myeloid leukemia.Haematologica · 2023Review
- Article
- Regulation of hematopoietic and leukemia stem cells by regulatory T cells.Frontiers in immunology · 2022Review
- Regulation of Malignant Myeloid Leukemia by Mesenchymal Stem Cells.Frontiers in cell and developmental biology · 2022Review
- Review
- TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.Cell reports · 2021Article
- Review
- Current Perspectives on the Role of TNF in Hematopoiesis Using Mice With Humanization of TNF/LT System.Frontiers in immunology · 2021Article
- Skeletal Stem Cells as the Developmental Origin of Cellular Niches for Hematopoietic Stem and Progenitor Cells.Current topics in microbiology and immunology · 2021Article
- The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution.Scientific reports · 2020Article
- Novel Approaches to Target Mutant FLT3 Leukaemia.Cancers · 2020Review
- Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia.Nature communications · 2020Article
- Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation.Stem cell reports · 2020Article
- Inferring Gene Networks in Bone Marrow Hematopoietic Stem Cell-Supporting Stromal Niche Populations.iScience · 2020Article
- Gilteritinib induces PUMA-dependent apoptotic cell death via AKT/GSK-3β/NF-κB pathway in colorectal cancer cells.Journal of cellular and molecular medicine · 2020Article
- Regulation of the Bone Marrow Niche by Inflammation.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 5 institutions in 4 countries.
Adam J MeadHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK adam.mead@imm.ox.ac.uk.ORCID http://orcid.org/0000-0001-8522-1002
Wen Hao NeoHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6827-3027
Nikolaos BarkasHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4675-0718
Sahoko MatsuokaDepartment of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan.
Alice GiustacchiniHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-8733-8594
Raffaella FacchiniHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6026-6893
Supat ThongjueaHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Lauren JamiesonHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Christopher A G BoothHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3841-6637
Nicholas FordhamHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7830-8465
Cristina Di GenuaHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3777-9578
Deborah AtkinsonHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Onima ChowdhuryHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-8150-4088
Emmanouela RepapiComputational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-8085-0731
Nicki GrayComputational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9149-0831
Shabnam KharaziDepartment of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Sally-Ann ClarkHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1720-7975
Tiphaine BouriezHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-8574-6068
Petter WollHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-2340-2526
Toshio SudaCancer Science Institute, National University of Singapore, Singapore.
Claus NerlovMedical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0544-735X
Sten Eirik W JacobsenHaematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK sten.eirik.jacobsen@ki.se.ORCID http://orcid.org/0000-0002-1362-3659
University of Oxford · GBKarolinska Institutet · SEKarolinska University Hospital · SENational Institute of Infectious Diseases · JPNational University of Singapore · SG
Funding
Medical Research Council G0501838Medical Research Council G0701761Medical Research Council G0801073Medical Research Council G0900892Medical Research Council G0902418Medical Research Council MC_PC_12020Medical Research Council MC_UU_00016/5Medical Research Council MC_UU_00016/7Medical Research Council MC_UU_12009/5Medical Research Council MC_UU_12009/7Medical Research Council MR/L006340/1Medical Research Council MR/M00919X/1Wellcome TrustWorldwide Cancer Research 11-0724
Abstract
Although previous studies suggested that the expression of FMS-like tyrosine kinase 3 (Flt3) initiates downstream of mouse hematopoietic stem cells (HSCs),
Indexed as
MutationAnimalsAnti-Inflammatory Agents, Non-SteroidalBone Marrow CellsBone Marrow TransplantationCell ProliferationCells, CulturedEtanerceptfms-Like Tyrosine Kinase 3Gene Expression ProfilingHematopoietic Stem CellsMesenchymal Stem CellsMice, Inbred C57BLMice, TransgenicReverse Transcriptase Polymerase Chain ReactionSingle-Cell AnalysisAnti-Inflammatory Agents, Non-SteroidalEtanerceptFLT3 protein, humanfms-Like Tyrosine Kinase 3Tumor Necrosis Factor-alpha
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.