Trial reportCirculation2017
Study Comparing Vein Integrity and Clinical Outcomes in Open Vein Harvesting and 2 Types of Endoscopic Vein Harvesting for Coronary Artery Bypass Grafting: The VICO Randomized Clinical Trial (Vein Integrity and Clinical Outcomes).
Trial report in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Pooled it
- An Expert Panel Review of Endoscopic Vein Harvesting Devices: Benefits, Limitations, and Clinical Insights.Interdisciplinary cardiovascular and thoracic surgery · 2025Review
- How I do it: Endoscope-assisted in situ arterial reconstruction of the lower limb.Journal of vascular surgery cases and innovative techniques · 2024Article
- The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease.Cells · 2022Review
- Graft flow assessment and early coronary artery bypass graft failure: a computed tomography analysis.Interactive cardiovascular and thoracic surgery · 2022Article
- Coronary Artery Bypass: Review of Surgical Techniques and Impact on Long-Term Revascularization Outcomes.Cardiology and therapy · 2021Review
- Endoscopic vein harvesting.Journal of thoracic disease · 2021Review
- Saphenous vein grafts in contemporary coronary artery bypass graft surgery.Nature reviews. Cardiology · 2020Review
- Twenty-Five Years of No-Touch Saphenous Vein Harvesting for Coronary Artery Bypass Grafting: Structural Observations and Impact on Graft Performance.Brazilian journal of cardiovascular surgery · 2020Review
- Endoscopic vein harvest: benefits beyond (a) reasonable doubt?Journal of thoracic disease · 2019Article
- Precision and targeted therapy in cardiac surgery.Journal of thoracic disease · 2018Article
- Validating innovations to improve recovery after heart surgery.Annals of translational medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCurrent consensus statements maintain that endoscopic vein harvesting (EVH) should be standard care in coronary artery bypass graft surgery, but vein quality and clinical outcomes have been questioned. The VICO trial (Vein Integrity and Clinical Outcomes) was designed to assess the impact of different vein harvesting methods on vessel damage and whether this contributes to clinical outcomes after coronary artery bypass grafting.
methodsIn this single-center, randomized clinical trial, patients undergoing coronary artery bypass grafting with an internal mammary artery and with 1 to 4 vein grafts were recruited. All veins were harvested by a single experienced practitioner. We randomly allocated 300 patients into closed tunnel CO
resultsThe open vein harvesting group demonstrated marginally better endothelial integrity in random samples (85% versus 88% versus 93% for closed tunnel EVH, open tunnel EVH, and open vein harvesting;
conclusionsOur study demonstrates that harvesting techniques affect the integrity of different vein layers, albeit only slightly. Secondary outcomes suggest that histological findings do not directly contribute to major adverse cardiac event outcomes. Gains in health status were observed, and cost-effectiveness was better with closed tunnel EVH. High-level experience with endoscopic harvesting performed by a dedicated specialist practitioner gives optimal results comparable to those of open vein harvesting. CLINICAL
trial registrationURL: https://www.isrctn.com. International Standard Randomised Controlled Trial Registry Number: 91485426.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.