ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01782365 (Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Slow Wave Sleep of a Daytime Nap in Patients With Mild Cognitive Impairment), which is not on this map. Cited by 129 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Slow Wave Sleep of a Daytime Nap in Patients With Mild Cognitive Impairment(MCI)
Who cites it
129 citing papers in PubMed, 7 syntheses or guidelines pooled it, 233 citations in OpenAlex.
- Biomarker use in predicting transcranial direct-current stimulation (tDCS) response: a systematic scoping review.Frontiers in psychiatry · 2026Pooled it
- Combined Use of Electroencephalography and Transcranial Electrical Stimulation: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Pharmacological and Non-Pharmacological Interventions to Improve Sleep in People with Cognitive Impairment: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025Pooled it
- Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.Journal of sleep research · 2021Pooled it
- The Effects of Transcranial Electrical Stimulation of the Brain on Sleep: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- New Methods, Old Brains-A Systematic Review on the Effects of tDCS on the Cognition of Elderly People.Frontiers in human neuroscience · 2021Pooled it
- A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies-Related Issues and Future Directions.Sensors (Basel, Switzerland) · 2020Pooled it
- Cognitive training and brain stimulation in patients with cognitive impairment: a randomized controlled trial.Alzheimer's research & therapy · 2024Trial
- Improving Sleep Quality, Daytime Sleepiness, and Cognitive Function in Patients with Dementia by Therapeutic Exercise and NESA Neuromodulation: A Multicenter Clinical Trial.International journal of environmental research and public health · 2023Trial
- Trial
- Acoustic enhancement of sleep slow oscillations in mild cognitive impairment.Annals of clinical and translational neurology · 2019Trial
- Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings.Nature communications · 2017Trial
- Sleep Spindles and Slow Oscillations as Potential Biomarkers and Therapeutic Targets in Mild-to-Moderate Alzheimer's Disease.Current neurology and neuroscience reports · 2026Review
- Enhancement of sleep slow wave activity using transcranial electrical stimulation with temporal interference: an interim analysis of the STRENGTHEN study.Communications medicine · 2026Article
- Nightmare disorder shows reduced slow oscillation-dominant spindle coupling in NREM sleep.Npj biological timing and sleep · 2026Article
- Noninvasive Brain Stimulation Techniques and Their Efficacy in Treating Cognition and Memory in Mild Cognitive Impairment and Alzheimer's Disease-A Systematic Review.Brain sciences · 2026Review
- SleepPACNet: new convolutional neural network considering phase-amplitude coupling for automatic sleep stage classification using single-channel electroencephalogram.Scientific reports · 2026Article
- Aging disrupts the temporal organization of slow oscillations beyond density reduction.PNAS nexus · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Modulation of slow and fast oscillations by direct current stimulation in the cerebral cortex in vitro.The Journal of physiology · 2026Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) not only involves loss of memory functions, but also prominent deterioration of sleep physiology, which is already evident at the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO; 0.5-1 Hz) and thalamocortical spindle activity (12-15 Hz) during sleep, and their temporal coordination, are considered critical for memory formation. We investigated the potential of slow oscillatory transcranial direct current stimulation (so-tDCS), applied during a daytime nap in a sleep-state-dependent manner, to modulate these activity patterns and sleep-related memory consolidation in nine male and seven female human patients with MCI. Stimulation significantly increased overall SO and spindle power, amplified spindle power during SO up-phases, and led to stronger synchronization between SO and spindle power fluctuations in EEG recordings. Moreover, visual declarative memory was improved by so-tDCS compared with sham stimulation and was associated with stronger synchronization. These findings indicate a well-tolerated therapeutic approach for disordered sleep physiology and memory deficits in MCI patients and advance our understanding of offline memory consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.