Evidence map›Paper›PMID 28637806›Full record

ArticleClinical and vaccine immunology : CVI2017

The Pneumococcal Serotype 15C Capsule Is Partially O-Acetylated and Allows for Limited Evasion of 23-Valent Pneumococcal Polysaccharide Vaccine-Elicited Anti-Serotype 15B Antibodies.

Brady L Spencer, Anukul T Shenoy, Carlos J Orihuela, Moon H Nahm

Abstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brady L SpencerDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Anukul T ShenoyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Carlos J OrihuelaDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Moon H NahmDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA nahm@uab.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Cardiac microlesion formation during invasive pneumococcal diseaseR01AI114800 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Carlos J Orihuela, Herve S TETTELIN · 2015 to 2026
$5.1M
Acquired deficiency of innate immunity (ficolin-2) among elderly adultsR01AG050607 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NAHM, MOON H. · 2015 to 2019
$1.6M
NCI NIH HHS P30 CA013148NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI114800NIA NIH HHS R01 AG050607
6 · The paper itself

Abstract

As a species,

Indexed as

Immune EvasionAcetylationAntibodies, BacterialBacterial CapsulesEnzyme-Linked Immunosorbent AssayHumansNasopharynxPhagocytosisPneumococcal InfectionsPneumococcal VaccinesPolysaccharides, BacterialSerogroupSerotypingStreptococcus pneumoniae23-valent pneumococcal capsular polysaccharide vaccineAntibodies, BacterialPneumococcal VaccinesPolysaccharides, Bacterialcapsular polysaccharidecapsule diversityO-acetylationO-acetyltransferasepneumococcal vaccinereplication slippageserotyping

Identifiers

PMID28637806
PMCPMC5583466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.