Evidence map›Paper›PMID 28637800›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Pharmacokinetics, Biodistribution, and Radiation Dosimetry for

Joseph A O'Donoghue, Jason S Lewis, Neeta Pandit-Taskar, Stephen E Fleming, Heiko Schöder, Steven M Larson, Volkan Beylergil, Shutian Ruan, Serge K Lyashchenko, Pat B Zanzonico and 3 more

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Trial
  3. Cancer discovery · 2019
    Trial
  4. First-in-Human Human Epidermal Growth Factor Receptor 2-Targeted Imaging UsingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Trial
  5. Materials today. Bio · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. [Molecular pharmaceutics · 2024
    Article
  14. Review
  15. Review
  16. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  17. EANM guidance document: dosimetry for first-in-human studies and early phase clinical trials.European journal of nuclear medicine and molecular imaging · 2024
    Article
  18. First-in-Human Evaluation of Site-Specifically LabeledJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  19. Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024
    Review
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Joseph A O'DonoghueDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Jason S LewisRadiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York.
Neeta Pandit-TaskarDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Stephen E FlemingDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Steven M LarsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Volkan BeylergilDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Shutian RuanDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Serge K LyashchenkoRadiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York.
Pat B ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Wolfgang A WeberDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jorge A CarrasquilloDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York carrasj1@mskcc.org.
Yelena Y JanjigianDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; and.
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Trastuzumab with chemotherapy improves clinical outcomes in patients with human epidermal growth factor receptor 2 (HER2)-positive esophagogastric adenocarcinoma (EGA). Despite the therapeutic benefit, responses are rarely complete, and most patients develop progression. To our knowledge, this is the first report evaluating

Indexed as

AdenocarcinomaAntibodies, Monoclonal, HumanizedEsophagogastric JunctionFemaleHumansMaleNeoplasm MetastasisPositron-Emission TomographyStomach NeoplasmsTissue DistributionAntibodies, Monoclonal, Humanizedzirconium-89-trastuzumab89Zresophageal cancergastric cancerHER2trastuzumab

Identifiers

PMID28637800
PMCPMC5750520
OpenAlexW2652858501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.