ArticleThe EMBO journal2017
A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.
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Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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0cells of the map it votes in
38citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
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Who cites it
38 citing papers in PubMed, 64 citations in OpenAlex.
- A novel role for TRPV1 in macrophage giant cell formation.bioRxiv : the preprint server for biology · 2026Article
- Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress.Journal of neuroendocrinology · 2026Article
- The Role of TRPV1 in Type 1 Diabetes.Biology · 2025Review
- Astrocytes modulate neuronal development by S100A6 signaling.Nature communications · 2025Article
- Secretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP Secretion.Journal of the Endocrine Society · 2025Article
- Article
- The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis.Cell death discovery · 2024Article
- Identification of unique cell type responses in pancreatic islets to stress.Nature communications · 2024Article
- A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Beta-Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Role of TRP Channels in Metabolism-Related Diseases.International journal of molecular sciences · 2024Review
- Roles of ubiquitin-specific proteases in inflammatory diseases.Frontiers in immunology · 2024Review
- Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α.Life medicine · 2023Article
- SCGN deficiency is a risk factor for autism spectrum disorder.Signal transduction and targeted therapy · 2023Article
- ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells.Acta biochimica et biophysica Sinica · 2022Article
- Disrupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of Type 2 Diabetes.Endocrinology · 2022Article
- Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns.Epigenetics & chromatin · 2022Article
- Transient receptor potential vanilloid subtype 1: A potential therapeutic target for fibrotic diseases.Frontiers in physiology · 2022Review
- An Autonomous Cannabinoid System in Islets of Langerhans.Frontiers in endocrinology · 2021Review
- Secretagogin is Related to Insulin Secretion but Unrelated to Gestational Diabetes Mellitus Status in Pregnancy.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 4 countries.
Katarzyna MalenczykDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Fatima GirachDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Edit SzodoraiDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Petter StormDepartment of Clinical Sciences, Diabetes and Endocrinology CRC, Skåne University Hospital Malmö, Malmö, Sweden.
Åsa SegerstolpeIntegrated Cardio Metabolic Centre, Karolinska Institutet, Huddinge, Sweden.
Giuseppe TortorielloDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Robert SchnellDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Jan MulderScience for Life Laboratory, Karolinska Institutet, Solna, Sweden.
Roman A RomanovDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Erzsébet BorókDepartment of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Fabiana PiscitelliEndocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli Naples, Italy.
Vincenzo Di MarzoEndocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli Naples, Italy.
Gábor SzabóInstitute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
Rickard SandbergIntegrated Cardio Metabolic Centre, Karolinska Institutet, Huddinge, Sweden.
Stefan KubicekCeMM Research Centre for Molecular Medicine, Vienna, Austria.
Gert LubecDepartment of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria.
Tomas HökfeltDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ludwig WagnerUniversity Clinic for Internal Medicine III, General Hospital Vienna, Vienna, Austria.
Leif GroopDepartment of Clinical Sciences, Diabetes and Endocrinology CRC, Skåne University Hospital Malmö, Malmö, Sweden.
Tibor HarkanyDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria tibor.harkany@meduniwien.ac.at.ORCID 0000-0002-6637-5900
Karolinska Institutet · SEMedical University of Vienna · ATIstituto di Chimica Biomolecolare · ITSkåne University Hospital · SECeMM Research Center for Molecular Medicine · ATHUN-REN Institute of Experimental Medicine · HUScience for Life Laboratory · SEUniversity of Vienna · ATVienna General Hospital · AT
Funding
European Research Council 695136
Abstract
Ca
Indexed as
Gene Expression RegulationAnimalsCell SurvivalGene Expression ProfilingHumansInsulin-Secreting CellsMiceMice, KnockoutProteinsSecretagoginsSingle-Cell AnalysisTRPV Cation ChannelsProteinsSCGN protein, humanSCGN protein, mouseSecretagoginsTRPV1 protein, humanTRPV1 protein, mouseTRPV Cation ChannelsCa2+ signallingdiabetesendocannabinoidexocytosisβ‐cell
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Textmetadata
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.