Observational studyJournal of the American Heart Association2017
Sex-Based Differences in the Performance of the HEART Score in Patients Presenting to the Emergency Department With Acute Chest Pain.
Observational study in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Diagnostic Accuracy Improvement of an Updated HEART Score to Predict Coronary Artery Disease as Detected by Coronary Computed Tomography Angiography.Journal of clinical medicine · 2026Article
- The Role of Sex and Gender in Precision Emergency Medicine: A Scoping Review and Proposed Hierarchy.Clinical therapeutics · 2024Article
- Characteristics and Outcomes of Patients With a Moderate History, ECG, Age, Risk Factors, and Troponin (HEART) Score.Cureus · 2024Article
- Sex-disparities in chest pain workup: a retrospective cohort review of a university based clinical decision pathway.BMC cardiovascular disorders · 2023Article
- Differences in risk and costs between prehospital identified low-risk men and women with chest pain.Open heart · 2023Article
- Achieving Equity in Emergency Medicine Quality Measures Requires a Sex and Gender Lens.The Journal of emergency medicine · 2023Article
- Applying the HEART score is safe and saves.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2022Article
- Contemporary Risk Stratification of Acute Coronary Syndrome.US cardiology · 2022Review
- Racial Variations in Emergency Department Management of Chest Pain in a Community-based Setting.Spartan medical research journal · 2022Article
- Prehospital risk stratification in patients with chest pain.Emergency medicine journal : EMJ · 2021Article
- Evaluating Sex Disparities in the Emergency Department Management of Patients With Suspected Acute Coronary Syndrome.Annals of emergency medicine · 2021Article
- Effectiveness of Modified HEART Score in Predicting Major Adverse Cardiac Events.The Eurasian journal of medicine · 2021Article
- Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain.PloS one · 2020Article
- Sex as a Biological Variable in Emergency Medicine Research and Clinical Practice: A Brief Narrative Review.The western journal of emergency medicine · 2017Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex-based differences in clinical presentation, pathophysiology, and outcomes of patients with acute chest pain are increasingly being recognized, but are not implemented in guidelines and clinical prediction tools. We evaluated the performance of the HEART score in women versus men, because sex-based differences may exist among the algorithm's components: history, electrocardiogram, age, risk factors, and admission troponin level. METHODS AND
resultsThe HEART score was retrospectively assessed in 831 women and 1084 men presenting to the emergency department with acute chest pain, assigning patients to the low-, intermediate-, or high-risk category for the occurrence of major adverse cardiac events (MACE) within 6 weeks. MACE, consisting of myocardial infarction, coronary revascularization, and all-cause death, also included events during index visit. Six-week MACE rates were 2 times lower in women than men (10.0% versus 20.8%;
conclusionsThe markedly higher 6-week MACE risk in men across all HEART risk categories should be taken into account when using the HEART score to guide clinical decision making; early discharge with a low-risk HEART score appears less safe for men than women with acute chest pain.
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Registered trials
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