Evidence map›Paper›PMID 28637751›Full record

ArticleJournal of virology2017

Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity.

Benjamin M Davis, Volker Fensterl, Tessa M Lawrence, Andrew W Hudacek, Ganes C Sen, Matthias J Schnell

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Sequence Diversity in the 3' Untranslated Region of Alphavirus Modulates IFIT2-Dependent Restriction in a Cell Type-Dependent Manner.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2025
    Article
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  10. Review
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  15. Review
  16. GluiScience · 2022
    Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Benjamin M DavisDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Volker FensterlDepartment of Immunology, Cleveland Clinic, Cleveland, Ohio, USA.
Tessa M LawrenceDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Andrew W HudacekDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Ganes C SenDepartment of Immunology, Cleveland Clinic, Cleveland, Ohio, USA.
Matthias J SchnellDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA Matthias.Schnell@jefferson.edu.ORCID http://orcid.org/0000-0001-9040-9405
Thomas Jefferson University · USCleveland Clinic · US

Funding

ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
ANTIVIRAL ACTIONS OF INTERFERONSR01CA068782 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI SEN, GANES C. · 1995 to 2020
$7.6M
Drug discovery against lyssaviruses by high thoughput screeningR01AI127823 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI PLEMPER, RICHARD K., SCHNELL, MATTHIAS JOHANNES · 2017 to 2019
$1.2M
Toward an Pan-lyssavirus vaccineR21AI128175 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SCHNELL, MATTHIAS JOHANNES · 2017 to 2018
$429k
NCI NIH HHS R01 CA068782NIAID NIH HHS R01 AI127823NIAID NIH HHS R21 AI128175NIH HHS P40 OD010996
6 · The paper itself

Abstract

Understanding the interactions between rabies virus (RABV) and individual host cell proteins is critical for the development of targeted therapies. Here we report that interferon-induced protein with tetratricopeptide repeats 2 (Ifit2), an interferon-stimulated gene (ISG) with possible RNA-binding capacity, is an important restriction factor for rabies virus. When Ifit2 was depleted, RABV grew more quickly in mouse neuroblastoma cells

Indexed as

AnimalsApoptosis Regulatory ProteinsBrainCell Line, TumorFemaleInterferonsMaleMiceMice, Inbred C57BLMice, KnockoutNeuroblastomaProteinsRabiesRabies virusRNA-Binding ProteinsRNA, Small InterferingApoptosis Regulatory ProteinsIfit2 protein, mouseInterferonsProteinsRNA-Binding ProteinsRNA, Small Interferinginnate immunityneurotropic virusesneurovirulencerabiesrhabdovirus

Identifiers

PMID28637751
PMCPMC5553164
OpenAlexW2640778550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.