Evidence map›Paper›PMID 28637692›Full record

ArticleGenes & development2017

m

Shengdong Ke, Amy Pandya-Jones, Yuhki Saito, John J Fak, Cathrine Broberg Vågbø, Shay Geula, Jacob H Hanna, Douglas L Black, James E Darnell, Robert B Darnell

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 386 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
386citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

386 citing papers in PubMed, 1 synthesis or guideline pooled it, 570 citations in OpenAlex.

  1. Pooled it
  2. NAR cancer · 2026
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  5. Review
  6. mNature reviews. Neuroscience · 2026
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  8. Nuclear mNature chemical biology · 2026
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  12. Comprehensive Profiling of NAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  15. Review
  16. Article
  17. Article
  18. NNature reviews. Cancer · 2026
    Review
  19. Review
  20. Article

326 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Shengdong KeLaboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10065, USA.
Amy Pandya-JonesDepartment of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA.
Yuhki SaitoLaboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10065, USA.
John J FakLaboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10065, USA.
Cathrine Broberg VågbøProteomics and Metabolomics Core Facility, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Shay GeulaThe Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Jacob H HannaThe Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Douglas L BlackDepartment of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA.
James E DarnellLaboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10065, USA.
Robert B DarnellLaboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10065, USA.
Rockefeller University · USHoward Hughes Medical Institute · USUniversity of California, Los Angeles · USWeizmann Institute of Science · ILNorwegian University of Science and Technology · NO

Funding

Combining New Molecular and Informatic Strategies to Find Hidden Ways to Treat Brain DiseaseR35NS097404 · NINDS · ROCKEFELLER UNIVERSITY · PI DARNELL, ROBERT B · 2017 to 2024
$9.0M
The Regulation of Neuronal Exon SplicingR01GM049662 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLACK, DOUGLAS L · 1998 to 2019
$6.5M
NEUROLOGY AND THE MOLECULAR ROLE OF N-RBPS IN THE BRAINR01NS034389 · NINDS · ROCKEFELLER UNIVERSITY · PI DARNELL, ROBERT B · 1995 to 2016
$6.3M
Mapping the mechanisms of protein synthesis-dependent synaptic plasticityR01NS081706 · NINDS · ROCKEFELLER UNIVERSITY · PI DARNELL, ROBERT B · 2012 to 2016
$5.3M
Neurology and the molecular role of N-RBPs in the brainR56NS034389 · NINDS · ROCKEFELLER UNIVERSITY · PI DARNELL, ROBERT B · 2012 to 2012
$590k
NIGMS NIH HHS R01 GM049662NINDS NIH HHS R01 NS034389NINDS NIH HHS R01 NS081706NINDS NIH HHS R35 NS097404NINDS NIH HHS R56 NS034389
6 · The paper itself

Abstract

Understanding the biologic role of

Indexed as

RNA SplicingAnimalsChromatinCytoplasmEmbryonic Stem CellsExonsGene Knockout TechniquesHeLa CellsHumansIntronsMethylationMethyltransferasesMiceRNA, MessengerRNA PrecursorsChromatinMethyltransferasesMettl3 protein, mouseRNA, MessengerRNA Precursorscell fractionationm6A-CLIPmRNA turnoverpre-mRNA

Identifiers

PMID28637692
PMCPMC5495127
OpenAlexW2632544498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.