Evidence map›Paper›PMID 28637689›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer.

Wei-Lei Yang, Aleksandra Gentry-Maharaj, Archana Simmons, Andy Ryan, Evangelia Ourania Fourkala, Zhen Lu, Keith A Baggerly, Yang Zhao, Karen H Lu, David Bowtell and 6 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04489706 (A Clinical Trial to Evaluate the Efficacy, Safety, and Tolerability of Arsenic Trioxide for Injection in Patients With Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 Mutation), which is not on this map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04489706 naunknown statusnot on this mapstarted 2020, after this paper: background citation

A Clinical Trial to Evaluate the Efficacy, Safety, and Tolerability of Arsenic Trioxide for Injection in Patients With Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 Mutation

TypeinterventionalSponsorRuijin HospitalRan2020 to 2022Enrolled20ConditionsOvarian Cancer, Endometrial CancerArmsArsenic trioxide for injection
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Molecular Management of High-Grade Serous Ovarian Carcinoma.International journal of molecular sciences · 2022
    Review
  11. A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer from Benign Pelvic Masses.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  12. Molecular Biomarkers for the Early Detection of Ovarian Cancer.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Wei-Lei YangUniversity of Texas MD Anderson Cancer Center, Houston, Texas.
Aleksandra Gentry-MaharajGynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, United Kingdom.
Archana SimmonsUniversity of Texas MD Anderson Cancer Center, Houston, Texas.
Andy RyanGynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, United Kingdom.
Evangelia Ourania FourkalaGynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, United Kingdom.
Zhen LuUniversity of Texas MD Anderson Cancer Center, Houston, Texas.
Keith A BaggerlyUniversity of Texas MD Anderson Cancer Center, Houston, Texas.
Yang ZhaoUniversity of Texas MD Anderson Cancer Center, Houston, Texas.
Karen H LuUniversity of Texas MD Anderson Cancer Center, Houston, Texas.
David Bowtell
Ian JacobsGynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, United Kingdom.
Steven J SkatesBiostatistics Center, Massachusetts General Hospital, Boston, Massachusetts.
Wei-Wu HeOriGene Technologies, Inc., Rockville, Maryland.
Usha MenonGynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, United Kingdom.
Robert C BastUniversity of Texas MD Anderson Cancer Center, Houston, Texas. rbast@mdanderson.org.
AOCS Study Group
The University of Texas MD Anderson Cancer Center · USBoston Medical Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
UNIVERSITY OF TEXAS MD ANDERSON SPORE IN OVARIAN CANCERP50CA083639 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C · 1999 to 2015
$33.0M
MD Anderson Cancer Center EDRN- CVC for Early Detection of Ovarian CancerU01CA200462 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ROBERT C BAST · 2016 to 2026
$9.3M
Proteomic, Genomic, and Longitudinal Pathways to Ovarian Cancer Biomarker DiscoveryU01CA152990 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BIRRER, MICHAEL, SKATES, STEVEN J · 2010 to 2021
$8.9M
U.T. M. D. Anderson Cancer Center SPORE in Ovarian CancerP50CA217685 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2017 to 2021
$7.9M
Cancer Research UK 12677Medical Research Council G0801228NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA083639NCI NIH HHS P50 CA217685NCI NIH HHS U01 CA152990NCI NIH HHS U01 CA200462
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAustraliaAutoantibodiesBiomarkers, TumorCA-125 AntigenCarcinoma, Ovarian EpithelialEarly Detection of CancerFemaleHumansMembrane ProteinsMiddle AgedNeoplasms, Glandular and EpithelialOvarian NeoplasmsTumor Suppressor Protein p53United KingdomAutoantibodiesBiomarkers, TumorCA-125 AntigenMembrane ProteinsMUC16 protein, humanTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID28637689
PMCPMC5626590
OpenAlexW2633266064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.