Evidence map›Paper›PMID 28637687›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Inhibition of CDK4/6 by Palbociclib Significantly Extends Survival in Medulloblastoma Patient-Derived Xenograft Mouse Models.

Michelle L Cook Sangar, Laura A Genovesi, Madison W Nakamoto, Melissa J Davis, Sue E Knobluagh, Pengxiang Ji, Amanda Millar, Brandon J Wainwright, James M Olson

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

  1. Trial
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  12. Mechanistic insights into medulloblastoma relapse.Pharmacology & therapeutics · 2024
    Review
  13. Article
  14. Review
  15. TheInternational journal of molecular sciences · 2024
    Article
  16. Review
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  18. Article
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michelle L Cook SangarClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Laura A GenovesiInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
Madison W NakamotoClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Melissa J DavisWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Sue E KnobluaghDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Pengxiang JiInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
Amanda MillarInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
Brandon J WainwrightInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
James M OlsonClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. jolson@fredhutch.org.

Funding

Testing a cancer patient-specific SARS-CoV-2 vaccine in chemotherapy- and radiation-treated pediatric brain tumor mouse modelsR01CA114567 · NCI · SEATTLE CHILDREN'S HOSPITAL · PI OLSON, JAMES M · 2006 to 2023
$4.9M
Chlorotoxin as a Targeting Agent for Cancer TherapiesR01CA135491 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OLSON, JAMES M · 2008 to 2018
$3.8M
Targeting Akt and Bcl-2 in Prostate Cancer PreventionR01CA112250 · NCI · OHIO STATE UNIVERSITY · PI CHEN, CHING-SHIH · 2005 to 2015
$2.8M
NCI NIH HHS R01 CA112250NCI NIH HHS R01 CA114567NCI NIH HHS R01 CA135491
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Molecular Targeted TherapyAnimalsCell ProliferationCyclin DCyclin-Dependent Kinase 4Disease Models, AnimalHedgehog ProteinsHumansMedulloblastomaMicePhosphorylationPiperazinesPrognosisProtein Interaction MapsProto-Oncogene Proteins c-mycPyridinesCDK4 protein, humanCyclin DCyclin-Dependent Kinase 4Hedgehog ProteinspalbociclibPiperazinesProto-Oncogene Proteins c-mycPyridines

Identifiers

PMID28637687
PMCPMC6939669

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.