Evidence map›Paper›PMID 28637674›Full record

ArticleAmerican journal of physiology. Cell physiology2017

Oxidative stress destabilizes protein arginine methyltransferase 4 via glycogen synthase kinase 3β to impede lung epithelial cell migration.

Xiuying Li, Yandong Lai, Jin Li, Mingyi Zou, Chunbin Zou

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The emerging role of CARM1 in cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
  5. Age-Dependent Inflammatory Microenvironment Mediates Alveolar Regeneration.International journal of molecular sciences · 2024
    Article
  6. Review
  7. Protein arginine methylation in viral infection and antiviral immunity.International journal of biological sciences · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiuying LiAcute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Yandong LaiAcute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Jin LiAcute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Mingyi ZouAcute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Chunbin ZouAcute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania zouc@upmc.edu.ORCID http://orcid.org/0000-0003-1355-4726
University of Pittsburgh · US

Funding

Epigenetic Regulation in Acute Lung InjuryR01HL125435 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZOU, CHUNBIN · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL125435
6 · The paper itself

Abstract

Oxidative stress impacts normal cellular function leading to the pathogenesis of various diseases including pulmonary illnesses. Protein arginine methyltransferase 4 (PRMT4) is critical for normal lung alveolar epithelial cell development; however, the regulation of PRMT4 within such pulmonary diseases has yet to be elucidated. Using biochemical approaches, we uncovered that peroxide (H

Indexed as

AnimalsCell LineCell MovementEnzyme StabilityEpithelial CellsGene Expression Regulation, EnzymologicGlycogen Synthase Kinase 3 betaMiceOxidative StressProtein-Arginine N-MethyltransferasesRespiratory MucosaWound Healingcoactivator-associated arginine methyltransferase 1Glycogen Synthase Kinase 3 betaGsk3b protein, mouseProtein-Arginine N-Methyltransferasesglycogen synthase kinase 3βGSK-3βmigrationoxidative stressphosphorylationPRMT4protein arginine methyltransferase 4ubiquitin and proteasome degradation

Identifiers

PMID28637674
PMCPMC5625095
OpenAlexW2721572384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.