ArticleChinese journal of cancer2017
Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China.
Article in Chinese journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Gender impact on pancreatic neuroendocrine neoplasm (PanNEN) prognosis according to survival nomograms.Endocrine · 2025Pooled it
- Systematic review of the use of big data to improve surgery in low- and middle-income countries.The British journal of surgery · 2019Pooled it
- A novel nomogram and risk stratification system predicting the cancer-specific survival of patients with gastric neuroendocrine carcinoma: a study based on SEER database and external validation.BMC gastroenterology · 2023Trial
- Development and validation of prognostic nomograms for patients with colon neuroendocrine neoplasms.World journal of surgical oncology · 2021Trial
- Renal small cell neuroendocrine carcinoma: a case report and literature review.International journal of surgery case reports · 2026Article
- Incidence and Survival of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms in the Contemporary Era.JAMA network open · 2026Article
- Primary Intrahepatic Biliary Neuroendocrine Neoplasms: A Case Report and Literature Review.Journal of gastrointestinal cancer · 2025Review
- Current advances in neuroendocrine neoplasms of the colon and rectum.World journal of clinical oncology · 2025Review
- Epidemiology of Neuroendocrine Neoplasia Worldwide: A Review of the Literature (2012-2022).Neuroendocrinology · 2025Review
- Article
- Nomogram prediction of overall survival in breast cancer patients post-surgery: integrating SEER database and multi-center evidence from China.Frontiers in oncology · 2024Article
- Lymph node ratio and hematological parameters predict relapse-free survival in patients with high grade rectal neuroendocrine neoplasms after radical resection: a multicenter prognostic study.World journal of surgical oncology · 2023Article
- Simultaneous rectal neuroendocrine tumors and pituitary adenoma: A case report and review of literature.World journal of gastroenterology · 2023Review
- Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre.BMC endocrine disorders · 2023Article
- Survival Analysis in Gastrointestinal Neuroendocrine Carcinoma With Bone Metastasis at Diagnosis.Frontiers in surgery · 2022Article
- Tumor size and perineural invasion predict outcome of gastric high-grade neuroendocrine neoplasms.Endocrine connections · 2021Article
- Risk Factors and Predictive Score Model for Early Recurrence After Curative Surgery in Patients With Poorly Differentiated Gastrointestinal Neuroendocrine Neoplasms.Frontiers in surgery · 2021Article
- Effects of tumor distance from anal verge on survival outcomes for rectal NENs and lymphatic metastasis risk score for colorectal NENs.International journal of colorectal disease · 2020Article
- Trends of incidence and prognosis of gastric neuroendocrine neoplasms: a study based on SEER and our multicenter research.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Label-free identification of early gastrointestinal neuroendocrine tumors via biomedical multiphoton microscopy and automatic image analysis.IEEE access : practical innovations, open solutions · 2020Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with GEP-NENs.
methodsComplete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China. Patient survival was estimated using the Kaplan-Meier method and analyzed using the log-rank test; prognostic factors were analyzed using the Cox proportional hazards model.
resultsThe most common tumor location was the rectum (37.4%), followed by the pancreas (28.1%), stomach (20.7%), small intestine (7.2%), appendix (3.4%), and colon (3.3%). After initial definitive diagnosis, 1016 (85.9%) patients underwent surgery. The 1-, 3-, and 5-year overall survival (OS) rates for the entire cohort were 87.9%, 78.5%, and 72.8%, respectively. The 3-year OS rates of patients with G1, G2, and G3 tumors were 93.1%, 82.7%, and 43.1%, respectively (P < 0.001). The 3-year OS rates of patients with stage I, II, III, and IV tumors were 96.0%, 87.3%, 64.0%, and 46.8%, respectively (P < 0.001). Patients with distant metastasis who underwent palliative surgery had a longer survival than those who did not (P = 0.003). Similar survival benefits of palliative surgery were observed in patients with neuroendocrine tumor (P = 0.031) or neuroendocrine carcinoma (P = 0.046). In multivariate analysis, age, grade, N category, M category, and surgery were found to be independent prognostic factors.
conclusionsPatients with GEP-NENs who are women, younger than 50 years old, have smaller tumor size, have lower tumor grade, have lower T/N/M category, and who undergo surgery can have potentially longer survival time. Our data showed that surgery can improve the prognosis of GEP-NEN patients with distant metastasis. However, randomized controlled trials need to be conducted to establish the optimal criteria for selecting patients to undergo surgery.
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