ArticleEuropean journal of medical research2017
Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study.
Article in European journal of medical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 37 citations in OpenAlex.
- Gestational Diabetes and Hypothyroidism: Do Other Factors Play a Role? A Retrospective Case-Control Study.Nursing research and practice · 2026Article
- Population-based national incidence of thyroid dysfunction in Spain.Scientific reports · 2025Observational
- Prevalence and associated factors of anxiety and depression among patients with hypothyroidism in Southern Iran.BMC psychiatry · 2025Article
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- Increased prevalence of thyroid dysfunction in Tehran - HAMRAH study.BMC endocrine disorders · 2023Article
- Unexpected high frequency of anti-thyroid peroxidase (anti-TPO) antibodies in Golestan province, Iran.Caspian journal of internal medicine · 2023Article
- A Thyroid Stimulating Hormone Reference Range: Iranian Thyroid Cohort study.Acta bio-medica : Atenei Parmensis · 2021Article
- Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Archives of endocrinology and metabolism · 2021Article
- Association of miR-499 Polymorphism and Its Regulatory Networks with Hashimoto Thyroiditis Susceptibility: A Population-Based Case-Control Study.International journal of molecular sciences · 2021Article
- Spatial Association between Gastric Cancer Mortality and Goiter in Sardinia.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Possible role of hypothyroidism in the prognosis of COVID-19.Internal medicine journal · 2020Article
- Vitamin D deficiency in non-autoimmune hypothyroidism: a case-control study.BMC endocrine disorders · 2020Article
- The effectiveness of cognitive- behavioral therapy on quality of life in women with hypothyroidism in the reproductive age: a randomized controlled trial.Thyroid research · 2020Article
- Epidemiology of hyperthyroidism in Iran: a systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of thyroid dysfunction is high in Isfahan, an area of iodine sufficient in Iran. The aim of this study is to investigate the incidence of thyroid dysfunctions in adults of metropolitan Isfahan and to determine the role of thyroid autoantibodies.
methodsIn a population-based cohort study in 2006-2011, we measured TSH, T4, T3, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) in 618 out of 2254 people who were euthyroid in 2006. The incidence rates per 1000 person-year (pr) were calculated. The odds ratio (OR), relative risk (RR), and 95% confidence interval (95% CI) were calculated based on logistic regression to quantify the potential predictors of thyroid dysfunction. The receiver-operator characteristic (ROC) analysis along with area under the curve (AUC) was used to determine the optimal cutoff values for baseline TPOAb and TgAb as predictors of thyroid dysfunction.
resultsWithin a 6-year follow-up, the incidence rate of hypothyroidism was 3.3 in women and 2.1 in men while the incidence rate of hyperthyroidism was 3.8 in women and none in men per 1000 (person-year). A cutoff value of TPOAb at 38 IU/mL was obtained to differentiate the patients with hypothyroidism and hyperthyroidism, with specificity of 0.75 and sensitivity of 0.76, and AUC (CI 95%) of 0.882 (0.743-1.02), P = 0.01 and 0.817 (0.600-1.035) P = 0.033, respectively. There is a statistically significant association of hypothyroidism and hyperthyroidism with positive TPOAb [RR (CI 95%): 1.99 (1.27-3.13) and 2.20 (1.23-3.95), respectively].
conclusionsThe incidence rate of thyroid dysfunction is high in Isfahan, and higher TPOAb concentration is its strong predictor.
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