Trial reportBMC cancer2017
Cerebellar mutism syndrome in children with brain tumours of the posterior fossa.
Trial report in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02300766 (Nordic Study of the Cerebellar Mutism Syndrome in Children With Brain Tumours of the Posterior Fossa), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nordic Study of the Cerebellar Mutism Syndrome in Children With Brain Tumours of the Posterior Fossa
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Neurological, Neuropsychological, and Social Outcomes in Pediatric Patients Diagnosed With Cerebellar Mutism Syndrome: A Systematic Review.Pediatric blood & cancer · 2025Pooled it
- Functional tracts of the cerebellum-essentials for the neurosurgeon.Neurosurgical review · 2021Pooled it
- Intraoperative neurophysiology of the cerebellum: a tabula rasa.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Pooled it
- Preoperative Speech Impairments as Precursors of Posterior Fossa Syndrome in Children with Brain Tumours.Cerebellum (London, England) · 2026Article
- Language Processing in Posterior Fossa Tumour Patients: Psycholinguistic Insights into the Word-Finding Ability.Cerebellum (London, England) · 2026Article
- Analysis of Presurgical Language in Children with Posterior Fossa Tumours Relative to Postoperative Speech Outcomes: Findings from the European CMS Study.Cerebellum (London, England) · 2026Article
- Evaluation of tractography parameters for dentato-rubro-thalamic tract reconstruction during pediatric posterior fossa tumor surgery.Magma (New York, N.Y.) · 2026Article
- Long-Term Outcomes Associated With Posterior Fossa Syndrome in Survivors of Childhood Medulloblastoma.JAMA network open · 2026Article
- Risk factors associated with cerebellar mutism syndrome and late postoperative hydrocephalus following pediatric posterior fossa medulloblastoma surgery.Frontiers in oncology · 2026Article
- Association between perioperative factors and the occurrence of postoperative cerebellar mutism syndrome in children.Frontiers in neurology · 2026Article
- Postoperative speech impairment and cranial nerve deficits in children undergoing posterior fossa tumor surgery with intraoperative MRI - a prospective multinational study.Acta neurochirurgica · 2025Observational
- Interobserver variability in assessing preoperative imaging biomarkers for cerebellar mutism syndrome: a multiobserver pilot study.Pediatric radiology · 2025Article
- Glucocorticoid use in paediatric posterior fossa tumour surgery and the occurrence of postoperative speech impairment.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Observational
- Tumour volume as a predictor of postoperative speech impairment in children undergoing resection of posterior fossa tumours: a prospective, multicentre study.Acta neurochirurgica · 2025Article
- Postoperative word-finding difficulties in children with posterior fossa tumours: a crosslinguistic European cohort study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Preoperative word-finding difficulties in children with posterior fossa tumours: a European cross-sectional study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Male Predisposition in Cerebellar Mutism Syndrome: a Cohort Study.Cerebellum (London, England) · 2023Article
- Radiotherapy-Induced Neurocognitive Dysfunction in Brain Tumor Survivors: Burden and Rehabilitation.Acta neurochirurgica. Supplement · 2023Article
- The Entity of Cerebellar Mutism Syndrome: A Narrative Review Centered on the Etiology, Diagnostics, Prevention, and Therapeutic Options.Children (Basel, Switzerland) · 2022Review
- A case of postoperative cerebellar mutism with hyperphagia in a child following gross total resection of medulloblastoma occupying the cerebellar vermis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 12 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of posterior fossa tumour surgery is the cerebellar mutism syndrome (CMS) which has been reported in up to 39% of the patients but the exact incidence is uncertain since milder cases may be unrecognized. Recovery is usually incomplete. Reported risk factors are tumour type, midline location and brainstem involvement, but the exact aetiology, surgical and other risk factors, the clinical course and strategies for prevention and treatment are yet to be determined.
methodsThis observational, prospective, multicentre study will include 500 children with posterior fossa tumours. It opened late 2014 with participation from 20 Nordic and Baltic centres. From 2016, five British centres and four Dutch centres will join with a total annual accrual of 130 patients. Three other major European centres are invited to join from 2016/17. Follow-up will run for 12 months after inclusion of the last patient. All patients are treated according to local practice. Clinical data are collected through standardized online registration at pre-determined time points pre- and postoperatively. Neurological status and speech functions are examined pre-operatively and postoperatively at 1-4 weeks, 2 and 12 months. Pre- and postoperative speech samples are recorded and analysed. Imaging will be reviewed centrally. Pathology is classified according to the 2007 WHO system. Germline DNA will be collected from all patients for associations between CMS characteristics and host genome variants including pathway profiles. DISCUSSION: Through prospective and detailed collection of information on 1) differences in incidence and clinical course of CMS for different patient and tumour characteristics, 2) standardized surgical data and their association with CMS, 3) diversities and results of other therapeutic interventions, and 4) the role of host genome variants, we aim to achieve a better understanding of risk factors for and the clinical course of CMS - with the ultimate goal of defining strategies for prevention and treatment of this severely disabling condition.
trial registrationClinicaltrials.gov : NCT02300766 , date of registration: November 21, 2014.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.