ArticleGenome biology and evolution2017
Evolution of Transcription Activator-Like Effectors in Xanthomonas oryzae.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- Two domesticated species of rice shaped the population structure of Xanthomonas oryzae pv. oryzae in Africa.PLoS pathogens · 2026Article
- Effector loss and gain drives host range at a fitness cost.PLoS pathogens · 2026Article
- Genomic insights into the TAL effector diversity and SWEET gene targeting in Indian strains of Xanthomonas oryzae pv. oryzae.Archives of microbiology · 2026Article
- The Rice-Xoc Arms Race: Molecular Mechanisms and Genomic Strategies Against Bacterial Leaf Streak.Rice (New York, N.Y.) · 2026Review
- Genome Evolution in Plant Pathogenic Bacteria.Genome biology and evolution · 2026Review
- Effector Triggered Susceptibility and Immunity in Bacterial Diseases of Leaf Blight and Streak in Rice.Rice (New York, N.Y.) · 2026Review
- Review
- Comparative genomics of native plasmids from plant pathogenic Gammaproteobacteria.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- Comparative genomics using long-read sequencing identifies nearly identical TAL effector regions in twoFrontiers in microbiology · 2025Article
- Development and Validation of an SNP Marker for Identifying Xanthomonas oryzae pv. oryzae Thai Isolates That Break xa5-Mediated Bacterial Blight Resistance in Rice.The plant pathology journal · 2024Article
- Designer TALEs enable discovery of cell death-inducer genes.Plant physiology · 2024Article
- Genetic Structure and TALome Analysis Highlight a High Level of Diversity in Burkinabe Xanthomonas Oryzae pv. oryzae Populations.Rice (New York, N.Y.) · 2023Article
- Review
- Complete Genomic Sequence ofInternational journal of molecular sciences · 2023Article
- Assembling highly repetitive Xanthomonas TALomes using Oxford Nanopore sequencing.BMC genomics · 2023Article
- Flexible TALEs for an expanded use in gene activation, virulence and scaffold engineering.Nucleic acids research · 2022Article
- Comparative Genomic Analysis of TwoFrontiers in microbiology · 2022Article
- An ERF121 transcription factor from Brassica oleracea is a target for the conserved TAL-effectors from different Xanthomonas campestris pv. campestris strains.Molecular plant pathology · 2021Article
- TAL Effector Repertoires of Strains ofMicroorganisms · 2021Article
- Genomics-Enabled Novel Insight Into the Pathovar-Specific Population Structure of the Bacterial Leaf Streak PathogenFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription activator-like effectors (TALEs) are secreted by plant-pathogenic Xanthomonas bacteria into plant cells where they act as transcriptional activators and, hence, are major drivers in reprogramming the plant for the benefit of the pathogen. TALEs possess a highly repetitive DNA-binding domain of typically 34 amino acid (AA) tandem repeats, where AA 12 and 13, termed repeat variable di-residue (RVD), determine target specificity. Different Xanthomonas strains possess different repertoires of TALEs. Here, we study the evolution of TALEs from the level of RVDs determining target specificity down to the level of DNA sequence with focus on rice-pathogenic Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc) strains. We observe that codon pairs coding for individual RVDs are conserved to a similar degree as the flanking repeat sequence. We find strong indications that TALEs may evolve 1) by base substitutions in codon pairs coding for RVDs, 2) by recombination of N-terminal or C-terminal regions of existing TALEs, or 3) by deletion of individual TALE repeats, and we propose possible mechanisms. We find indications that the reassortment of TALE genes in clusters is mediated by an integron-like mechanism in Xoc. We finally study the effect of the presence/absence and evolutionary modifications of TALEs on transcriptional activation of putative target genes in rice, and find that even single RVD swaps may lead to considerable differences in activation. This correlation allowed a refined prediction of TALE targets, which is the crucial step to decipher their virulence activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.