Evidence map›Paper›PMID 28636966›Full record

ArticleImmunity2017

The TORC that Gets the GC Cycling.

Elissa K Deenick, Stuart G Tangye

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elissa K DeenickImmunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW, Australia. Electronic address: e.deenick@garvan.org.au.
Stuart G TangyeImmunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW, Australia.
Garvan Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The signaling pathways regulating positive selection in germinal centers (GCs) are incompletely understood. Ersching et al. (2017) identify a critical but temporal role for the action of the kinase mechanistic target of rapamycin complex (mTORC1), which promotes key changes in GC B cells and thereby facilitates affinity maturation.

Indexed as

B-LymphocytesGerminal CenterHumansSignal Transduction

Identifiers

PMID28636966
OpenAlexW2636644429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.