ArticleCell reports2017
The Sensory Striatum Is Permanently Impaired by Transient Developmental Deprivation.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Hearing Loss and Parkinson's Disease: Insights From Human and Animal Studies.Brain and behavior · 2026Article
- Striatal output regulates the postnatal maturation of cortical circuits.Cell reports · 2025Article
- Article
- Auditory decision-making deficits after permanent noise-induced hearing loss.Scientific reports · 2025Article
- Formation of an auditory sensory representation in posterior striatum emerges during a brief temporal window of associative learning in normal and hearing-impaired gerbils.Frontiers in systems neuroscience · 2025Article
- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Organization of orbitofrontal-auditory pathways in the Mongolian gerbil.The Journal of comparative neurology · 2023Article
- An Animal Model of Neonatal Intensive Care Unit Exposure to Light and Sound in the Preterm Infant.Integrative and comparative biology · 2023Article
- Auditory processing remains sensitive to environmental experience during adolescence in a rodent model.Nature communications · 2022Article
- Conservation of the Direct and Indirect Pathway Dichotomy in Mouse Caudal Striatum With Uneven Distribution of Dopamine Receptor D1- and D2-Expressing Neurons.Frontiers in neuroanatomy · 2022Article
- Early Sensory Deprivation Leads to Differential Inhibitory Changes in the Striatum During Learning.Frontiers in neural circuits · 2021Article
- Histaminergic Control of Corticostriatal Synaptic Plasticity during Early Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- An integrative framework for perceptual disturbances in psychosis.Nature reviews. Neuroscience · 2019Review
- Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons.The Journal of physiology · 2019Article
- Preserving Inhibition during Developmental Hearing Loss Rescues Auditory Learning and Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Partial decortication ameliorates dopamine depletion‑induced striatal neuron lesions in rats.International journal of molecular medicine · 2019Article
- Functional brain alterations following mild-to-moderate sensorineural hearing loss in children.eLife · 2019Article
- Effects of Non-traumatic Noise and Conductive Hearing Loss on Auditory System Function.Neuroscience · 2019Review
- Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals.eLife · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Corticostriatal circuits play a fundamental role in regulating many behaviors, and their dysfunction is associated with many neurological disorders. In contrast, sensory disorders, like hearing loss (HL), are commonly linked with processing deficits at or below the level of the auditory cortex (ACx). However, HL can be accompanied by non-sensory deficits, such as learning delays, suggesting the involvement of regions downstream of ACx. Here, we show that transient developmental HL differentially affected the ACx and its downstream target, the sensory striatum. Following HL, both juvenile ACx layer 5 and striatal neurons displayed an excitatory-inhibitory imbalance and lower firing rates. After hearing was restored, adult ACx neurons recovered balanced excitatory-inhibitory synaptic gain and control-like firing rates, but striatal neuron synapses and firing properties did not recover. Thus, a brief period of abnormal cortical activity may induce cellular impairments that persist into adulthood and contribute to neurological disorders that are striatal in origin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.