ArticlePloS one2017
Predictive value of serum transthyretin for outcome in acute ischemic stroke.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study.International journal of molecular sciences · 2024Article
- Serum Prealbumin Levels and Risks of Adverse Clinical Outcomes After Ischemic Stroke.Clinical epidemiology · 2024Article
- Nutritional Biomarkers as Predictors of Dysphonia Severity in Patients with Ischemic Stroke.Nutrients · 2023Article
- Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications.Circulation research · 2022Review
- Serum Prealbumin Levels on Admission as a Prognostic Marker in Stroke Patients Treated with Mechanical Thrombectomy.Cerebrovascular diseases extra · 2022Article
- Association between serum transthyretin and intracranial atherosclerosis in patients with acute ischemic stroke.Frontiers in neurology · 2022Article
- Exploring the Physiological Role of Transthyretin in Glucose Metabolism in the Liver.International journal of molecular sciences · 2021Article
- Impact of a High-protein Nutritional Intake on the Clinical Outcome of the Neurocritical Patients.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Serum Proteome Alterations in Human Cystathionine β-Synthase Deficiency and Ischemic Stroke Subtypes.International journal of molecular sciences · 2019Article
- CSF Proteomics of Patients with Hydrocephalus and Subarachnoid Haemorrhage.Translational neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe impact of choroid plexus with its blood-cerebrospinal fluid barrier in the ischemic stroke pathology is poorly explored. Transthyretin (TTR) is a protein synthesized in liver and just in choroid plexus.
objectivesThe current study was designed to assess the prognostic value of serum TTR for functional outcome (at the time of hospital discharge) and long-term (one-year) overall mortality in ischemic stroke patients. PATIENTS AND
methodsWe conducted a prospective observational study. Patients (n = 81) with acute (< 24 hours of symptoms onset) ischemic stroke consecutively admitted to Stroke Unit were included. An unfavorable outcome was defined as a modified Rankin Scale (mRS) score ≥ 3. The relationships between serum TTR levels and clinical outcome were analyzed using multivariate analysis. One-year mortality was analyzed by Kaplan-Meier survival curves stratified by mean value of TTR.
resultsCompared with patients with mRS <3, patients with an unfavorable outcome at hospital discharge had significantly lower TTR levels on admission (P < 0.0001). In non-survivals serum TTR levels were significantly lower compared with patients who survive one year of observation (P = 0.009). Using multivariate analysis, transthyretin emerged as an independent predictor for unfavorable outcome at the day of hospital discharge (adjusted odds ratio = 0.96; 95% CI: 0.9-0.99, P <0.05). A one-year mortality of patients with the lower TTR levels was significantly higher than in patients with TTR levels above mean value (P = 0.02).
conclusionsSerum level of TTR at admission was a predictor of functional outcome after ischemic stroke and was also associated with one-year mortality in stroke survivals.
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