ArticlePloS one2017
In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- HIV-associated preeclampsia: evaluation of lymphangiogenesis in placental bed samples.Histochemistry and cell biology · 2025Article
- Parental Preconception Posttraumatic Stress Symptoms and Maternal Prenatal Inflammation Prospectively Predict Shorter Telomere Length in Children.Psychosomatic medicine · 2024Article
- Association between maternal cardiometabolic markers and fetal growth in non-complicated pregnancies: a secondary analysis of the PRINCESA cohort.Scientific reports · 2024Article
- Prenatal mood and anxiety disorders and associated cytokine changes.Journal of affective disorders · 2024Article
- The dynamic inflammatory profile of pregnancy can be monitored using a novel lipid-based mass spectrometry technique.Molecular omics · 2023Article
- Breast Carcinogenesis during Pregnancy: Molecular Mechanisms, Maternal and Fetal Adverse Outcomes.Biology · 2023Review
- Hs-CRP and TNF-α Effects on Postnatal Umbilical Coiling: Impact Assessment of the Gestational Diabetes Mellitus.Medical journal of the Islamic Republic of Iran · 2023Article
- Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity.Clinical and experimental immunology · 2022Article
- Neurological consequences of neurovascular unit and brain vasculature damages: potential risks for pregnancy infections and COVID-19-babies.The FEBS journal · 2022Review
- Maternal diet and obesity shape offspring central and peripheral inflammatory outcomes in juvenile non-human primates.Brain, behavior, and immunity · 2022Article
- Placental Ultrasonographic Findings Due to COVID-19 Infection During Pregnancy: A Case Report.Cureus · 2022Article
- Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction.Evolution, medicine, and public health · 2022Article
- Ambient air pollution and inflammatory effects in a Canadian pregnancy cohort.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Comprehensive analysis of COVID-19 during pregnancy.Biochemical and biophysical research communications · 2021Review
- A systematic review and meta-analysis of the correlation between maternal and neonatal iron status and haematologic indices.EClinicalMedicine · 2020Article
- Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination.Vaccines · 2020Review
- Major Variation in the Incidence of Appendicitis Before, During and After Pregnancy: A Population-Based Cohort Study.World journal of surgery · 2020Article
- Relationships between objective sleep parameters and inflammatory biomarkers in pregnancy.Annals of the New York Academy of Sciences · 2020Article
- Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua.Scientific reports · 2020Article
- Innate Lymphoid Cells in Human Pregnancy.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in maternal innate immunity during healthy human pregnancy are not well understood. Whether basal immune status in vivo is largely unaffected by pregnancy, is constitutively biased towards an inflammatory phenotype (transiently enhancing host defense) or exhibits anti-inflammatory bias (reducing potential responsiveness to the fetus) is unclear. Here, in a longitudinal study of healthy women who gave birth to healthy infants following uncomplicated pregnancies within the Canadian Healthy Infant Longitudinal Development (CHILD) cohort, we test the hypothesis that a progressively altered bias in resting innate immune status develops. Women were examined during pregnancy and again, one and/or three years postpartum. Most pro-inflammatory cytokine expression, including CCL2, CXCL10, IL-18 and TNFα, was reduced in vivo during pregnancy (20-57%, p<0.0001). Anti-inflammatory biomarkers (sTNF-RI, sTNF-RII, and IL-1Ra) were elevated by ~50-100% (p<0.0001). Systemic IL-10 levels were unaltered during vs. post-pregnancy. Kinetic studies demonstrate that while decreased pro-inflammatory biomarker expression (CCL2, CXCL10, IL-18, and TNFα) was constant, anti-inflammatory expression increased progressively with increasing gestational age (p<0.0001). We conclude that healthy resting maternal immune status is characterized by an increasingly pronounced bias towards a systemic anti-inflammatory innate phenotype during the last two trimesters of pregnancy. This is resolved by one year postpartum in the absence of repeat pregnancy. The findings provide enhanced understanding of immunological changes that occur in vivo during healthy human pregnancy.
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