ArticleEnvironmental health perspectives2017
Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case-Control Study (New England, USA).
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Exposure to Drinking Water Trihalomethanes and Risk of Cancer: A Systematic Review of the Epidemiologic Evidence and Dose-Response Meta-Analysis.Environmental health perspectives · 2025Pooled it
- Disinfection By-Products in Drinking Water and Bladder Cancer: Evaluation of Risk Modification by Common Genetic Polymorphisms in Two Case-Control Studies.Environmental health perspectives · 2022Pooled it
- Drinking Water Contaminant Exposures and Risk of Uterine Cancer.JAMA network open · 2026Article
- Malignant Transformation of Human Uroepithelial Cells Induced by Long-Term Exposure to a Disinfection Byproduct2,6-Dichlorobenzoquinone.Environment & health (Washington, D.C.) · 2025Article
- Evaluating Powdered Activated Carbon for Adsorption of Nitrogenous Organics in Water Using HDPairFinder.ACS environmental Au · 2025Article
- Quantitative Evaluation of Regulatory Indicators for Brominated Haloacetic Acids in Drinking Water.Environmental science & technology · 2025Article
- Invited Perspective: Drinking Water Disinfection By-Products and Cancer-A Historical Perspective.Environmental health perspectives · 2025Article
- Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations.Environmental health perspectives · 2023Article
- Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.Environmental health perspectives · 2023Review
- Estimating National Exposures and Potential Bladder Cancer Cases Associated with Chlorination DBPs in U.S. Drinking Water.Environmental health perspectives · 2022Article
- Disinfection byproducts in chlorinated or brominated swimming pools and spas: Role of brominated DBPs and association with mutagenicity.Journal of environmental sciences (China) · 2022Article
- Drinking water sources and water quality in a prospective agricultural cohort.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Drinking Water Disinfection Byproducts, Ingested Nitrate, and Risk of Endometrial Cancer in Postmenopausal Women.Environmental health perspectives · 2022Article
- Fluorescent probe for the detection of hypochlorous acid in water samples and cell models.RSC advances · 2021Article
- Trihalomethanes in Water Supply System and Water Distribution Networks.International journal of environmental research and public health · 2021Article
- A review on the 40th anniversary of the first regulation of drinking water disinfection by-products.Environmental and molecular mutagenesis · 2020Review
- Analysis of Cumulative Cancer Risk Associated with Disinfection Byproducts in United States Drinking Water.International journal of environmental research and public health · 2020Article
- Occupational bladder cancer: A cross section survey of previous employments, tasks and exposures matched to cancer phenotypes.PloS one · 2020Article
- Ingested Nitrate and Nitrite and Bladder Cancer in Northern New England.Epidemiology (Cambridge, Mass.) · 2020Article
- Trihalomethanes in Drinking Water and Bladder Cancer Burden in the European Union.Environmental health perspectives · 2020Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIngestion of disinfection byproducts has been associated with bladder cancer in multiple studies. Although associations with other routes of exposure have been suggested, epidemiologic evidence is limited.
objectivesWe evaluated the relationship between bladder cancer and total, chlorinated, and brominated trihalomethanes (THMs) through various exposure routes.
methodsIn a population-based case–control study in New England (
resultsAdjusted ORs for bladder cancer comparing participants with exposure above the 95th percentile with those in the lowest quartile of exposure (based on the distribution in controls) were statistically significant for average daily intake mg/d of total THMs [OR=1.53 (95% CI: 1.01, 2.32),
conclusionsWe observed a modest association between ingestion of water with higher THMs (>95th percentile vs.<25th percentile) and bladder cancer. Brominated THMs have been a particular concern based on toxicologic evidence, and our suggestive findings for multiple metrics require further study in a population with higher levels of these exposures. Data from this population do not support an association between swimming pool use and bladder cancer. https://doi.org/10.1289/EHP89.
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