Evidence map›Paper›PMID 28636425›Full record

ArticleAmerican journal of respiratory and critical care medicine2017

American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.

Prescott G Woodruff, Maarten van den Berge, Richard C Boucher, Christopher Brightling, Esteban G Burchard, Stephanie A Christenson, MeiLan K Han, Michael J Holtzman, Monica Kraft, David A Lynch and 8 more

Open access · greenAbstract readConsensus Statement
In one paragraph

Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Genome-wide Association Study IdentifiesAllergy, asthma & immunology research · 2026
    Article
  7. Review
  8. Natural Experiments: An Efficient Tool for Population Respiratory Health Evaluation.American journal of respiratory and critical care medicine · 2025
    Article
  9. Article
  10. Article
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  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 5 countries.

Prescott G Woodruff1 Division of Pulmonary and Critical Care, University of California, San Francisco, California.
Maarten van den Berge2 Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Richard C Boucher3 Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina.
Christopher Brightling4 Respiratory Biomedical Research Unit, Leicester, United Kingdom.
Esteban G Burchard1 Division of Pulmonary and Critical Care, University of California, San Francisco, California.
Stephanie A Christenson1 Division of Pulmonary and Critical Care, University of California, San Francisco, California.
MeiLan K Han5 Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, Michigan.
Michael J Holtzman6 Division of Pulmonary and Critical Care, Washington University, St. Louis, Missouri.
Monica Kraft7 Department of Medicine and.
David A Lynch8 Division of Oncology, National Jewish Health, Denver, Colorado.
Fernando D Martinez9 Division of Pulmonary and Sleep Medicine, University of Arizona, Tucson, Arizona.
Helen K Reddel10 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Don D Sin11 Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
George R Washko12 Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Sally E Wenzel13 Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Antonello Punturieri14 Division of Lung Diseases, NHLBI/National Institutes of Health, Bethesda, Maryland; and.
Michelle M Freemer14 Division of Lung Diseases, NHLBI/National Institutes of Health, Bethesda, Maryland; and.
Robert A Wise15 Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland.
University of California, San Francisco · USNational Institutes of Health · USHarvard University · USJohns Hopkins University · USNational Jewish Health · USNIHR Leicester Cardiovascular Biomedical Research Unit · GBThe University of Sydney · AUUniversity Medical Center Groningen · NLUniversity of Arizona · USUniversity of British Columbia · CAUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USWashington University in St. Louis · US

Funding

SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
Tissue and Cell Processing CoreU19AI070489 · NIAID · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2006 to 2016
$17.9M
Preclinical Development of an Anti-Mucus DrugUH3HL123429 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2016 to 2018
$4.7M
IL-33 AND EXCESS MUCUS PRODUCTIONR01HL121791 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2014 to 2017
$1.9M
TREM2 AND AIRWAY DISEASER01HL120153 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2016 to 2018
$1.3M
Mentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2M
Identifying the Th2 endotype in COPD: clinical and pathologic implicationsK23HL123778 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTENSON, STEPHANIE A · 2015 to 2019
$847k
NHLBI NIH HHS K23 HL123778NHLBI NIH HHS K24 HL137013NHLBI NIH HHS R01 HL120153NHLBI NIH HHS R01 HL121791NHLBI NIH HHS U01 HL137880NHLBI NIH HHS UH3 HL123429NIAID NIH HHS U19 AI070489
6 · The paper itself

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic obstructive lung diseases with an associated high burden of disease. Asthma, which is often allergic in origin, frequently begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, and dyspnea. Patients with COPD, in contrast, are usually current or former smokers who present after the age of 40 years with symptoms (often persistent) including dyspnea and a productive cough. On the basis of age and smoking history, it is often easy to distinguish between asthma and COPD. However, some patients have features compatible with both diseases. Because clinical studies typically exclude these patients, their underlying disease mechanisms and appropriate treatment remain largely uncertain. To explore the status of and opportunities for research in this area, the NHLBI, in partnership with the American Thoracic Society, convened a workshop of investigators in San Francisco, California on May 14, 2016. At the workshop, current understanding of asthma-COPD overlap was discussed among clinicians, pathologists, radiologists, epidemiologists, and investigators with expertise in asthma and COPD. They considered knowledge gaps in our understanding of asthma-COPD overlap and identified strategies and research priorities that will advance its understanding. This report summarizes those discussions.

Indexed as

AsthmaDiagnostic ImagingLungNational Heart, Lung, and Blood Institute (U.S.)Pulmonary Disease, Chronic ObstructiveSocieties, MedicalUnited Statesasthmachronic obstructive pulmonary diseaseoverlap

Identifiers

PMID28636425
PMCPMC5549872
OpenAlexW2651023859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.