Evidence map›Paper›PMID 28636424›Full record

ArticleCell adhesion & migration2018

Fluid shear stress regulates HepG2 cell migration though time-dependent integrin signaling cascade.

Hongchi Yu, Yang Shen, Jingsi Jin, Yingying Zhang, Tang Feng, Xiaoheng Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  3. Review
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  7. Direct mechanical exposure initiates hepatocyte proliferation.JHEP reports : innovation in hepatology · 2023
    Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Fluid Shear Stress Promotes Autophagy in Hepatocellular Carcinoma Cells.International journal of biological sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hongchi Yua Institute of Biomedical Engineering , School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , China.
Yang Shena Institute of Biomedical Engineering , School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , China.
Jingsi Jina Institute of Biomedical Engineering , School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , China.
Yingying Zhanga Institute of Biomedical Engineering , School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , China.
Tang Fenga Institute of Biomedical Engineering , School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , China.
Xiaoheng Liua Institute of Biomedical Engineering , School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a subtype of malignant liver cancer with poor prognosis and limited treatment options. It is noteworthy that mechanical forces in tumor microenvironment play a pivotal role in mediating the behaviors and functions of tumor cells. As an instrumental type of mechanical forces in vivo, fluid shear stress (FSS) has been reported having potent physiologic and pathologic effects on cancer progression. However, the time-dependent mechanochemical transduction in HCC induced by FSS remains unclear. In this study, hepatocellular carcinoma HepG2 cells were exposed to 1.4 dyn/cm

Indexed as

Stress, MechanicalCarcinoma, HepatocellularCell AdhesionCell MovementHep G2 CellsHumansIntegrinsLiver NeoplasmsPhosphorylationTime FactorsUp-RegulationIntegrinsadhesionfluid shear stresshepatocellular carcinomaintegrinsmigrationtumor microenvironment

Identifiers

PMID28636424
PMCPMC5810774
OpenAlexW2680648889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.