Evidence map›Paper›PMID 28636211›Full record

ArticleClinical transplantation2017

Resolution of donor non-alcoholic fatty liver disease following liver transplantation.

Andrew D Posner, Samuel T Sultan, Norann A Zaghloul, William S Twaddell, David A Bruno, Steven I Hanish, William R Hutson, Laci Hebert, Rolf N Barth, John C LaMattina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew D PosnerUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Samuel T SultanDivision of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5575-9693
Norann A ZaghloulUniversity of Maryland School of Medicine, Baltimore, MD, USA.
William S TwaddellUniversity of Maryland School of Medicine, Baltimore, MD, USA.
David A BrunoDivision of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA.
Steven I HanishDivision of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA.
William R HutsonUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Laci HebertDivision of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA.
Rolf N BarthDivision of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA.
John C LaMattinaDivision of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7016-0382

Funding

Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Basal body regulation of glucose homeostasisR01DK102001 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2014 to 2018
$1.7M
NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK102001
6 · The paper itself

Abstract

introductionTransplant surgeons conventionally select against livers displaying high degrees (>30%) of macrosteatosis (MaS), out of concern for primary non-function or severe graft dysfunction. As such, there is relatively limited experience with such livers, and the natural history remains incompletely characterized. We present our experience of transplanted livers with high degrees of MaS and microsteatosis (MiS), with a focus on the histopathologic and clinical outcomes.

methodsTwenty-nine cases were identified with liver biopsies available from both the donor and the corresponding liver transplant recipient. Donor liver biopsies displayed either MaS or MiS ≥15%, while all recipients received postoperative liver biopsies for cause.

resultsThe mean donor MaS and MiS were 15.6% (range 0%-60%) and 41.3% (7.5%-97.5%), respectively. MaS decreased significantly from donor (M=15.6%) to recipient postoperative biopsies (M=0.86%), P<.001. Similarly, MiS decreased significantly from donor biopsies (M=41.3%) to recipient postoperative biopsies (M=1.8%), P<.001. At a median of 68 days postoperatively (range 4-384), full resolution of MaS and MiS was observed in 27 of 29 recipients.

conclusionsHigh degrees of MaS and MiS in donor livers resolve in recipients following liver transplantation. Further insight into the mechanisms responsible for treating fatty liver diseases could translate into therapeutic targets.

Indexed as

Donor SelectionHepatectomyLiver TransplantationLiving DonorsAdultAgedBiopsyFemaleHumansLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseOutcome Assessment, Health CareRetrospective StudiesTransplantation, Homologousbiopsydonors and donation: extended criterialiver allograft function/dysfunction

Identifiers

PMID28636211
PMCPMC5856244

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.