Evidence map›Paper›PMID 28636132›Full record

ArticleGlia2017

TRPC1- and TRPC3-dependent Ca

Thabet Belkacemi, Alexander Niermann, Laura Hofmann, Ulrich Wissenbach, Lutz Birnbaumer, Petra Leidinger, Christina Backes, Eckart Meese, Andreas Keller, Xianshu Bai and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Glia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C-induced mechanical hypersensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Distribution and Assembly of TRP Ion Channels.Advances in experimental medicine and biology · 2021
    Article
  12. Article
  13. Article
  14. Astrocytic Calcium Dynamics Along the Pain Pathway.Frontiers in cellular neuroscience · 2020
    Review
  15. TRPC1 as a negative regulator for TRPC4 and TRPC5 channels.Pflugers Archiv : European journal of physiology · 2019
    Review
  16. Prediction of itching diagnostic marker through RNA sequencing of contact hypersensitivity and skin scratching stimulation mice models.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2019
    Article
  17. AMPA Receptor-Mediated CaFrontiers in cellular neuroscience · 2019
    Article
  18. Dual action of the GαScientific reports · 2018
    Article
  19. Ischemic Brain Injury Leads to Brain Edema via Hyperthermia-Induced TRPV4 Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Thabet BelkacemiExperimentelle und Klinische Pharmakologie und Toxikologie, Homburg, 66421, Germany.
Alexander NiermannExperimentelle und Klinische Pharmakologie und Toxikologie, Homburg, 66421, Germany.
Laura HofmannExperimentelle und Klinische Pharmakologie und Toxikologie, Homburg, 66421, Germany.
Ulrich WissenbachExperimentelle und Klinische Pharmakologie und Toxikologie, Homburg, 66421, Germany.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA.
Petra LeidingerInstitut für Humangenetik, Homburg, 66421, Germany.
Christina BackesKlinische Bioinformatik, Universität des Saarlandes, Saarbrücken, 66123, Germany.
Eckart MeeseInstitut für Humangenetik, Homburg, 66421, Germany.
Andreas KellerKlinische Bioinformatik, Universität des Saarlandes, Saarbrücken, 66123, Germany.
Xianshu BaiMolekulare Physiologie, Universität des Saarlandes, Homburg, 66421, Germany.
Anja SchellerMolekulare Physiologie, Universität des Saarlandes, Homburg, 66421, Germany.
Frank KirchhoffMolekulare Physiologie, Universität des Saarlandes, Homburg, 66421, Germany.
Stephan E PhilippExperimentelle und Klinische Pharmakologie und Toxikologie, Homburg, 66421, Germany.
Petra WeissgerberExperimentelle und Klinische Pharmakologie und Toxikologie, Homburg, 66421, Germany.
Veit FlockerziExperimentelle und Klinische Pharmakologie und Toxikologie, Homburg, 66421, Germany.
Andreas BeckExperimentelle und Klinische Pharmakologie und Toxikologie, Homburg, 66421, Germany.ORCID 0000-0002-2056-9005
Saarland University · DEPraxis für Humangenetik · DEPontificia Universidad Católica Argentina · AR

Funding

Transmembrane Signaling Mechanisms Involving TRP ChannelsZ01ES101684 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$2.1M
Intramural NIH HHS Z01 ES101684
6 · The paper itself

Abstract

Following brain injury astrocytes change into a reactive state, proliferate and grow into the site of lesion, a process called astrogliosis, initiated and regulated by changes in cytoplasmic Ca

Indexed as

AnimalsAstrocytesBrain EdemaCalcium SignalingCell MovementCell ProliferationCerebral CortexDisease Models, AnimalGliosisHEK293 CellsHumansMaleMice, 129 StrainMice, Inbred C57BLMice, KnockoutTRPC6 Cation Channeltransient receptor potential cation channel, subfamily C, member 1TRPC3 cation channelTrpc5 protein, mouseTRPC6 Cation ChannelTrpc6 protein, mouseTRPC Cation Channelsgliaion channelsmembrane currentsmigrationproliferationstab wound injury

Identifiers

PMID28636132
PMCPMC5526095
OpenAlexW2649840530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.