SynthesisEuropean journal of human genetics : EJHG2017
Genetically predicted high body mass index is associated with increased gastric cancer risk.
Synthesis in European journal of human genetics : EJHG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.BMC medicine · 2021Pooled it
- Mendelian randomization studies of gastric cancer reveal potential risk factors, promising biomarkers and therapeutic targets.Discover oncology · 2025Article
- Beneath the Surface: The Emerging Role of Ultra-Processed Foods in Obesity-Related Cancer.Current oncology reports · 2025Review
- Genetically predicted dietary intake and risks of colorectal cancer: a Mendelian randomisation study.BMC cancer · 2024Article
- Bioinformatics analysis of the association between obesity and gastric cancer.Frontiers in genetics · 2024Article
- Artificially sweetened beverages consumption and risk of obesity-related cancers: a wide-angled Mendelian randomization study.Frontiers in nutrition · 2024Article
- Evaluation of polygenic risk score for risk prediction of gastric cancer.World journal of gastrointestinal oncology · 2023Review
- Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management.Cancers · 2023Review
- The causal association between obesity and gastric cancer and shared molecular signatures: a large-scale Mendelian randomization and multi-omics analysis.Frontiers in oncology · 2023Article
- The Role of Mendelian Randomization Studies in Deciphering the Effect of Obesity on Cancer.Journal of the National Cancer Institute · 2022Article
- Cancer prevention through weight control-where are we in 2020?British journal of cancer · 2021Review
- BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization.Obesity (Silver Spring, Md.) · 2018Article
- The genetics of adiposity.Current opinion in genetics & development · 2018Review
- Mendelian randomization studies of cancer risk: a literature review.Current epidemiology reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have linked body mass index (BMI) with risk of gastrointestinal cancers. However, for gastric cancer, the relationship is more controversial. In particular, it is unclear whether the observed association is due to confounding or bias inherent in conventional observational studies. To investigate whether BMI is causally associated with gastric cancer risk, we applied Mendelian randomization using individual-level data from 2631 gastric cancer cases and 4373 cancer-free controls. We derived a weighted genetic risk score (wGRS) using 37 BMI-associated genetic variants as an instrumental variable. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between genetically predicted BMI and gastric cancer risk. We observed that higher genetically determined BMI was associated with increased gastric cancer risk (per standard deviation (SD) increase in the wGRS: OR=1.07, 95% CI: 1.02-1.13, P=4.94 × 10
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.