Evidence map›Paper›PMID 28635660›Full record

ArticleInternational journal of molecular sciences2017

Diverse Regulation of Vitamin D Receptor Gene Expression by 1,25-Dihydroxyvitamin D and ATRA in Murine and Human Blood Cells at Early Stages of Their Differentiation.

Sylwia Janik, Urszula Nowak, Agnieszka Łaszkiewicz, Anastasiia Satyr, Michał Majkowski, Aleksandra Marchwicka, Łukasz Śnieżewski, Klaudia Berkowska, Marian Gabryś, Małgorzata Cebrat and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Modeling the Hematopoietic Landscape.Frontiers in cell and developmental biology · 2019
    Review
  10. Article
  11. Article
  12. Acute Myeloid Leukaemia: New Targets and Therapies.International journal of molecular sciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sylwia JanikLaboratory of Molecular and Cellular Immunology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Science, Weigla 12, 53-114 Wrocław, Poland. sw90@interia.pl.
Urszula NowakLaboratory of Protein Biochemistry, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland. urszula.nowak.bio@gmail.com.
Agnieszka ŁaszkiewiczLaboratory of Molecular and Cellular Immunology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Science, Weigla 12, 53-114 Wrocław, Poland. bijbo@interia.pl.
Anastasiia SatyrLaboratory of Protein Biochemistry, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland. anastasiia.satyr@gmail.com.
Michał MajkowskiLaboratory of Molecular and Cellular Immunology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Science, Weigla 12, 53-114 Wrocław, Poland. michal.majkowski@iitd.pan.wroc.pl.
Aleksandra MarchwickaLaboratory of Protein Biochemistry, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland. alexandramarchwicka@interia.pl.
Łukasz ŚnieżewskiLaboratory of Molecular and Cellular Immunology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Science, Weigla 12, 53-114 Wrocław, Poland. lukasz.sniezewski@iitd.pan.wroc.pl.
Klaudia BerkowskaLaboratory of Protein Biochemistry, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland. airealphiel@wp.pl.
Marian GabryśFirst Department of Obstetrics and Gynecology, Wrocław Medical University, Chałubińskiego 3, 50-368 Wrocław, Poland. mst_gabrys@post.pop.pl.
Małgorzata CebratLaboratory of Molecular and Cellular Immunology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Science, Weigla 12, 53-114 Wrocław, Poland. cebrat@iitd.pan.wroc.pl.
Ewa MarcinkowskaLaboratory of Protein Biochemistry, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland. ema@cs.uni.wroc.pl.
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy · PLUniversity of Wrocław · PLWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D receptor (VDR) is present in multiple blood cells, and the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is essential for the proper functioning of the immune system. The role of retinoic acid receptor α (RARα) in hematopoiesis is very important, as the fusion of RARα gene with PML gene initiates acute promyelocytic leukemia where differentiation of the myeloid lineage is blocked, followed by an uncontrolled proliferation of leukemic blasts. RARα takes part in regulation of

Indexed as

Gene Expression RegulationAnimalsBlood CellsCell DifferentiationCell Line, TumorCells, CulturedHematopoiesisHL-60 CellsHumansLeukemia, Myeloid, AcuteMiceMice, Inbred C57BLReceptors, CalcitriolRetinoic Acid 4-HydroxylaseTretinoinVitamin D1,25-dihydroxyvitamin DReceptors, CalcitriolRetinoic Acid 4-HydroxylaseTretinoinVitamin Dblood cellsCYP24A1CYP26A1differentiationexpressionhematopoietic stem cellsretinoic acid receptorsvitamin D receptor

Identifiers

PMID28635660
PMCPMC5486144
OpenAlexW2704607352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.