Trial reportNutrients2017
Despite Inflammation, Supplemented Essential Amino Acids May Improve Circulating Levels of Albumin and Haemoglobin in Patients after Hip Fractures.
Trial report in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Post-surgery interventions for hip fracture: a systematic review of randomized controlled trials.BMC musculoskeletal disorders · 2023Pooled it
- Trial
- Trial
- Essential Amino Acid Supplementation May Attenuate Systemic Inflammation and Improve Hypoalbuminemia in Subacute Hemiplegic Stroke Patients.Metabolites · 2025Article
- Edaravone dextrocamphorol combined with intravenous thrombolysis enhances recovery in acute ischemic stroke.American journal of translational research · 2025Article
- Predictors for 1-year mortality in geriatric patients following fragile intertrochanteric fracture surgery.Journal of orthopaedic surgery and research · 2024Article
- Association between amino acids and recent osteoporotic fracture: a matched incident case-control study.Frontiers in nutrition · 2024Article
- Glucose-albumin ratio (GAR) as a novel biomarker of postoperative urinary tract infection in elderly hip fracture patients.Frontiers in medicine · 2024Article
- Consideration of the role of protein quality in determining dietary protein recommendations.Frontiers in nutrition · 2024Review
- Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation.Current osteoporosis reports · 2023Review
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance.Journal of the International Society of Sports Nutrition · 2023Article
- What Are the Barriers to Incorporating Nutrition Interventions Into Care of Older Adults With Femoral Fragility Fractures?The Iowa orthopaedic journal · 2023Review
- Correlation between admission hypoalbuminemia and postoperative urinary tract infections in elderly hip fracture patients.Journal of orthopaedic surgery and research · 2023Observational
- Nutritional Supplementation and Exercise as Essential Allies in the Treatment of Chronic Heart Failure: The Metabolic and Molecular Bases.Nutrients · 2023Review
- Hemodialysis Treatment Influences Postoperative Activities of Daily Living Improvement for Patients with Hip Fractures.Progress in rehabilitation medicine · 2023Article
- Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery.Nutrients · 2021Review
- Inflammation, pressure ulcers and poor functional status predict negative rehabilitation outcomes in postacute geriatric patients.Aging clinical and experimental research · 2021Article
- Observational
- Influence of Diets with Varying Essential/Nonessential Amino Acid Ratios on Mouse Lifespan.Nutrients · 2019Article
- The relationship between plasma amino acids and circulating albumin and haemoglobin in postabsorptive stroke patients.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential amino acids (EAAs) are nutritional substrates that promote body protein synthesis; thus we hypothesised that their supplementation may improve circulating albumin (Alb) and haemoglobin (Hb) in rehabilitative elderly patients following hip fractures (HF). Out of the 145 HF patients originally enrolled in our study, 112 completed the protocol. These subjects were divided into two randomised groups, each containing 56 patients. For a period of two months, one group (age 81.4 ± 8.1 years; male/female 27/29) received a placebo, and the other (age 83.1 ± 7.5 years; male/female 25/31) received 4 + 4 g/day oral EAAs. At admission, the prevalence of both hypoAlb (<3.5 g/dL) and hypoHb (<13 g/dL male, <12 g/dL female) was similar in the placebo group (64.3% hypoAlb, 66% hypoHb) and the treated group of patients (73.2% hypoAlb, 67.8% hypoHb). At discharge, however, the prevalence of hypoAlb had reduced more in EAAs than in placebo subjects (31.7% in EAAs vs. 77.8% in placebo;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.