Evidence map›Paper›PMID 28635632›Full record

ArticleNutrients2017

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.

Ana Burgeiro, Manuela G Cerqueira, Bárbara M Varela-Rodríguez, Sara Nunes, Paula Neto, Frederico C Pereira, Flávio Reis, Eugénia Carvalho

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  5. Strategies for optimization of hypoglycemia rat models.Animal models and experimental medicine · 2025
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  13. Exploring the Biological Effects of Anti-Diabetic Vanadium Compounds in the Liver, Heart and Brain.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
  14. Article
  15. Article
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  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ana BurgeiroCenter of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal. burgeiroana@gmail.com.
Manuela G CerqueiraCenter of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal. manuela.g.cerqueira@gmail.com.
Bárbara M Varela-RodríguezCenter of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal. biobvr00@udc.es.
Sara NunesCenter of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal. sara_nunes20@hotmail.com.
Paula NetoService of Anatomical Pathology, Coimbra University Hospital Centre (CHUC), 3000-075 Coimbra, Portugal. anahepafr@gmail.com.
Frederico C PereiraCenter of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal. fredcp@ci.uc.pt.
Flávio ReisCenter of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal. freis@fmed.uc.pt.
Eugénia CarvalhoCenter of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal. ecarvalh@cnc.uc.pt.
University of Coimbra · PTArkansas Children's Hospital · US

Funding

RESOURCE CORE 3: ANALYTICAL COREP30AG028718 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI WEI, JEANNE Y · 2011 to 2015
$5.1M
Effects of amino acids on regional lipid metabolismR01AG033761 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BORSHEIM, ELISABET · 2009 to 2013
$1.6M
NIA NIH HHS P30 AG028718NIA NIH HHS R01 AG033761
6 · The paper itself

Abstract

Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid metabolism in insulin-target organs (liver, skeletal muscle, and white adipose tissue) in a rat model treated with a high-sucrose (HSu) diet. Two groups of 16-week-old male Wistar rats underwent a 9-week protocol: HSu diet (

Indexed as

Lipid MetabolismAdiposityAnimalsBlood GlucoseDiabetes Mellitus, Type 2Dietary SucroseDisease Models, AnimalFastingGlucose-6-PhosphataseGlucose Transporter Type 1Glucose Transporter Type 2InsulinInsulin ResistanceLiverMaleMuscle, SkeletalBlood GlucoseDietary SucroseGlucose-6-PhosphataseGlucose Transporter Type 1Glucose Transporter Type 2InsulinSlc2a1 protein, mouseSlc2a2 protein, mouseTriglyceridesglucosehigh-sucrose diethypertriglyceridemialipidmetabolismprediabetes

Identifiers

PMID28635632
PMCPMC5490617
OpenAlexW2610245120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.